Houston vs Gonzaga Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 1 seed Houston Cougars (31-4) and the No. 8 seed Gonzaga Bulldogs (26-8) will play in the NCAA Tournament with a ticket to the Sweet 16 of the Midwest Region bracket on the line on Saturday at INTRUST Bank Arena, starting at 8:40 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Gonzaga Game Info and Odds

• Game day: Saturday, March 22, 2025
• Game time: 8:40 p.m. ET
• TV channel: TNT
• Location: Wichita, Kansas
• Arena: INTRUST Bank Arena

Houston vs. Gonzaga Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Houston win (63.7%)

Before making a bet on Saturday's Houston-Gonzaga spread (Houston -5.5) or total (141.5 points), take a look at the betting insights and trends below.

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Houston vs. Gonzaga: ATS Betting Stats and Trends

• Houston has covered 20 times in 34 chances against the spread this season.
• Gonzaga has won 15 games against the spread this season, while failing to cover 19 times.
• Against the spread, the Cougars have fared worse at home, covering 10 times in 17 home games, and seven times in 10 road games.
• The Bulldogs' winning percentage against the spread at home is .286 (4-10-0). On the road, it is .600 (6-4-0).

Houston vs. Gonzaga: Moneyline Betting Stats

• Houston has been victorious in 29, or 87.9%, of the 33 contests it has been chosen as moneyline favorites in this season.
• This season, the Cougars have come away with a win 25 times in 28 chances when named as a favorite of at least -205 or shorter on the moneyline.
• Gonzaga is the moneyline underdog in its first game this season.
• The Bulldogs have never played a game this season with moneyline odds of +168 or longer.
• Houston has an implied victory probability of 67.2% according to the moneyline set for this matchup.

Houston vs. Gonzaga Head-to-Head Comparison

• Houston's +573 scoring differential (outscoring opponents by 16.4 points per game) is a result of scoring 74.3 points per game (158th in college basketball) while allowing 57.9 per contest (first in college basketball).
• LJ Cryer's team-leading 15.2 points per game ranks 245th in the country.
• Gonzaga has a +582 scoring differential, topping opponents by 17.1 points per game. It is putting up 86.7 points per game, second in college basketball, and is allowing 69.6 per outing to rank 95th in college basketball.
• Graham Ike's team-leading 17 points per game rank him 112th in college basketball.
• The Cougars rank 117th in college basketball at 33 rebounds per game. That's 6.5 more than the 26.5 their opponents average.
• J'wan Roberts' 6.2 rebounds per game lead the Cougars and rank 279th in college basketball play.
• The 34.9 rebounds per game the Bulldogs accumulate rank 38th in the country, 6.1 more than the 28.8 their opponents collect.
• Ike's 7.4 rebounds per game lead the Bulldogs and rank 120th in the country.
• Houston records 102.3 points per 100 possessions (39th in college basketball), while allowing 79.8 points per 100 possessions (first in college basketball).
• The Bulldogs' 108.8 points per 100 possessions on offense rank second in college basketball, and the 87.3 points they concede per 100 possessions rank 38th in college basketball.

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