Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 1 on Oct. 3

Odds updated as of 8:11 p.m.

On Saturday in the MLB, the Cleveland Guardians are up against the Chicago White Sox for Game 1 of the ALDS.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Saturday, October 3, 2026
• Time: 1 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: truTV, TBS, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-154) | CHW: (+130)
• Spread: CLE: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 6.5 -- Over: (-134) | Under: (+110)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 12-9, 2.56 ERA vs Hagen Smith (White Sox) - 3-3, 1.29 ERA

The Guardians will look to Parker Messick (12-9, 2.56 ERA) versus the White Sox and Hagen Smith (3-3, 1.29 ERA). Messick and his team are 16-16-0 ATS this season when he starts. Messick's team is 12-12 this season when he starts and they are the moneyline favorite. Smith has started two games with set spreads, and the White Sox went 1-1-0. The White Sox were the moneyline underdog for one Smith start this season -- they won.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (60.4%)

Guardians vs White Sox Moneyline

• Chicago is a +130 underdog on the moneyline, while Cleveland is a -154 favorite at home.

Guardians vs White Sox Spread

• The Guardians are 1.5-run home favorites on the runline against the White Sox. The Guardians are +150 to cover, and the White Sox are -182.

Guardians vs White Sox Over/Under

• A total of 6.5 runs has been set for the Guardians-White Sox game on Oct. 3, with the over available at -134 and the under at +110.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been favorites in 90 games this season and have come away with the win 48 times (53.3%) in those contests.
• This season Cleveland has been victorious 19 times in 28 chances when named as a favorite of at least -154 on the moneyline.
• The Guardians and their opponents have hit the over in 74 of their 152 games with a total set by oddsmakers this season.
• The Guardians are 73-79-0 against the spread in their 152 games with a line set by sportsbooks this season.
• The White Sox have won 52 of the 107 games they were the moneyline underdog this season (48.6%).
• When playing as a moneyline underdog with odds of +130 or longer, Chicago has a 13-19 record (winning 40.6% of its games).
• In the 161 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 91 times (91-69-1).
• The White Sox are 92-69-0 ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 142 hits, batting .287 this season with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• Among all qualified hitters in baseball, he ranks 16th in batting average, 24th in on-base percentage, and 43rd in slugging.
• DeLauter has recorded at least one hit in two games in a row. During his last five outings he is hitting .200 with two doubles, a home run, three walks and two RBIs.
• Steven Kwan leads the Guardians with an OPS of .731. He has a slash line of .282/.382/.349 this season.
• He is 21st in batting average, seventh in on-base percentage and 131st in slugging in MLB.
• Jose Ramirez has 111 hits this season and has a slash line of .235/.320/.368.
• Brayan Rocchio has 15 home runs, 73 RBI and a batting average of .253 this season.
• Rocchio brings a two-game hitting streak into this matchup. In his last five games he is hitting .316 with a double, two home runs, a walk and three RBIs.

White Sox Player Leaders

• Miguel Vargas is batting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He's slugging .474 with an on-base percentage of .363.
• Including all the qualified hitters in the big leagues, he ranks 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth's .415 slugging percentage leads his team. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualified players, he ranks 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage.
• Sam Antonacci has put up a team-best .370 on-base percentage.
• Munetaka Murakami's 94 hits pace his team.

Guardians vs White Sox Head to Head

• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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