Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 1:12 a.m.

MLB action on Thursday includes the Cleveland Guardians taking on the Minnesota Twins.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Twins Game Info

• Cleveland Guardians (17-13) vs. Minnesota Twins (13-18)
• Date: Thursday, May 1, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: MLB Network, CLEG, and MNNT

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | MIN: (-102)
• Spread: CLE: +1.5 (-192) | MIN: -1.5 (+158)
• Total: 9 -- Over: (-118) | Under: (-104)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Edward Lively (Guardians) - 1-2, 4.40 ERA vs Simeon Woods Richardson (Twins) - 2-2, 4.07 ERA

The Guardians will call on Edward Lively (1-2) against the Twins and Simeon Woods Richardson (2-2). Lively and his team have a record of 3-3-0 against the spread when he starts. Lively's team won his only start as a favorite this season. The Twins are 3-1-0 against the spread when Richardson starts. The Twins were the underdog on the moneyline for one Richardson start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.3%)

Guardians vs Twins Moneyline

• Minnesota is a -102 underdog on the moneyline, while Cleveland is a -116 favorite at home.

Guardians vs Twins Spread

• The Twins are 1.5-run favorites against the spread for this matchup with the Guardians. The Twins are +158 to cover, while the Guardians are -192 to cover as a 1.5-run underdog on the runline.

Guardians vs Twins Over/Under

• Guardians versus Twins, on May 1, has an over/under of 9, with the over being -118 and the under -104.

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Guardians vs Twins Betting Trends

• The Guardians have been victorious in eight, or 72.7%, of the 11 contests they have been chosen as favorites in this season.
• Cleveland has a record of 8-2 in contests when sportsbooks favor them by -116 or more on the moneyline.
• The Guardians and their opponents have gone over in 16 of their 29 games with a total set by sportsbooks this season.
• The Guardians have posted a record of 13-16-0 against the spread this season.
• The Twins have put together a 1-6 record in games they were the underdog on the moneyline (winning 14.3% of those games).
• Minnesota has a 1-5 record (winning only 16.7% of its games) when playing as a moneyline underdog of -102 or longer.
• In the 30 games oddsmakers have set an over/under for the Twins, they have combined with opponents to go over the total 11 times (11-16-3).
• The Twins have covered 50% of their games this season, going 15-15-0 against the spread.

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.836) this season. He has a .322 batting average, an on-base percentage of .370, and a slugging percentage of .466.
• Among qualified batters in baseball, his batting average ranks 11th, his on-base percentage ranks 34th, and he is 45th in slugging.
• Jose Ramirez is batting .264 with five doubles, five home runs and nine walks. He's slugging .453 with an on-base percentage of .317.
• Among qualifying hitters, his batting average ranks him 63rd, his on-base percentage 86th, and his slugging percentage 55th.
• Kyle Manzardo leads Cleveland in total hits (20) this season, and 12 of those have gone for extra bases.
• Gabriel Arias has been key for Cleveland with 24 hits, an OBP of .313 plus a slugging percentage of .462.

Twins Player Leaders

• Ty France has racked up a team-best OBP (.341) and slugging percentage (.404). He's batting .266.
• Including all the qualifying hitters in the big leagues, his batting average ranks 59th, his on-base percentage ranks 58th, and he is 87th in slugging.
• France heads into this game on a five-game hitting streak. During his last five outings he is batting .450 with three doubles, a home run and six RBI.
• Byron Buxton has racked up 26 hits to pace his team. He has a batting average of .239 while slugging .477 with an on-base percentage of .274.
• His batting average is 93rd among all qualified players, his on-base percentage ranks 134th, and he is 39th in slugging.
• Trevor Larnach has two doubles, four home runs and 14 walks while hitting .236.
• Ryan Jeffers is hitting .256 with seven doubles, a home run and nine walks.

Guardians vs Twins Head to Head

• 4/30/2025: 4-2 CLE (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/28/2025: 11-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2024: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/17/2024: 4-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2024: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2024: 5-3 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 6-3 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/9/2024: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/19/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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