Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for April 30

Odds updated as of 1:12 a.m.

The Cleveland Guardians will take on the Minnesota Twins in MLB action on Wednesday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Twins Game Info

• Cleveland Guardians (16-13) vs. Minnesota Twins (13-17)
• Date: Wednesday, April 30, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and MNNT

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | MIN: (+110)
• Spread: CLE: -1.5 (+158) | MIN: +1.5 (-192)
• Total: 8 -- Over: (-105) | Under: (-115)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 2-3, 5.96 ERA vs Pablo Lopez (Twins) - 2-1, 2.08 ERA

The Guardians will look to Luis Ortiz (2-3) against the Twins and Pablo Lopez (2-1). Ortiz and his team have a record of 2-3-0 against the spread when he starts. Ortiz's team is 2-1 this season when he starts and they are the moneyline favorite. When Lopez starts, the Twins have gone 3-1-0 against the spread. The Twins were the moneyline underdog for one Lopez start this season -- they lost.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52%)

Guardians vs Twins Moneyline

• Minnesota is a +110 underdog on the moneyline, while Cleveland is a -130 favorite at home.

Guardians vs Twins Spread

• The Guardians are 1.5-run home favorites on the runline against the Twins. The Guardians are +158 to cover, and the Twins are -192.

Guardians vs Twins Over/Under

• A combined run total of 8 has been set for Guardians-Twins on April 30, with the over at -105 and the under at -115.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have been victorious in eight, or 72.7%, of the 11 contests they have been chosen as favorites in this season.
• Cleveland has a record of 5-1 when favored by -130 or more this year.
• Contests with the Guardians have gone over the total set by oddsmakers in 16 of 28 chances this season.
• The Guardians have an against the spread mark of 12-16-0 in 28 games with a line this season.
• The Twins have gone 1-6 in games they were listed as the moneyline underdog (winning 14.3% of those games).
• Minnesota has played as a moneyline underdog of +110 or longer in just two games this season, which it lost both.
• In the 29 games oddsmakers have set an over/under for the Twins, they have combined with opponents to go over the total 11 times (11-15-3).
• The Twins have a 15-14-0 record against the spread this season (covering 51.7% of the time).

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.865) this season. He has a .333 batting average, an on-base percentage of .382, and a slugging percentage of .482.
• Among all qualifying hitters, he is seventh in batting average, his on-base percentage ranks 26th, and he is 41st in slugging.
• Jose Ramirez is hitting .255 with four doubles, five home runs and nine walks. He's slugging .441 with an on-base percentage of .310.
• Among qualifiers, he is 72nd in batting average, 96th in on-base percentage and 55th in slugging percentage.
• Kyle Manzardo leads Cleveland with 20 hits. He is batting .227 this season and 12 of his hits have gone for extra bases.
• Manzardo enters this matchup with three games in a row with at least one hit. In his last five games he is hitting .263 with a double, a home run, a walk and two RBI.
• Gabriel Arias is batting .270 with a .313 OBP and 11 RBI for Cleveland this season.
• Arias has hit safely in five straight games. In his last five games he is hitting .263 with three doubles and an RBI.

Twins Player Leaders

• Ty France has an on-base percentage of .345 and a slugging percentage of .410. Both lead the Twins. He's batting .267.
• Including all the qualified players in the big leagues, he ranks 59th in batting average, 60th in on-base percentage and 80th in slugging percentage.
• France hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .421 with three doubles, a home run, a walk and six RBI.
• Byron Buxton leads his team with 25 hits. He has a batting average of .238 while slugging .486 with an on-base percentage of .274.
• Including all qualifying players, he ranks 95th in batting average, 135th in on-base percentage and 37th in slugging percentage.
• Trevor Larnach is batting .223 with two doubles, four home runs and 13 walks.
• Ryan Jeffers is hitting .257 with seven doubles, a home run and nine walks.

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