Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 9

Odds updated as of 7:15 a.m.

The Tuesday slate in MLB includes a matchup between the Cleveland Guardians and the Kansas City Royals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Royals Game Info

• Cleveland Guardians (73-70) vs. Kansas City Royals (73-71)
• Date: Tuesday, September 9, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSKC

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | KC: (+108)
• Spread: CLE: -1.5 (+162) | KC: +1.5 (-196)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 4-3, 3.73 ERA vs Noah Cameron (Royals) - 7-6, 3.03 ERA

The Guardians will give the ball to Joey Cantillo (4-3, 3.73 ERA), who is eyeing win No. 5 on the season, and the Royals will counter with Noah Cameron (7-6, 3.03 ERA). Cantillo and his team have a record of 5-4-0 against the spread when he starts. Cantillo's team is 3-2 this season when he starts and they are the moneyline favorite. When Cameron starts, the Royals have gone 11-8-0 against the spread. The Royals are 3-7 in Cameron's 10 starts this season that they were the moneyline underdog.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (54.3%)

Guardians vs Royals Moneyline

• The Guardians vs Royals moneyline has Cleveland as a -126 favorite, while Kansas City is a +108 underdog on the road.

Guardians vs Royals Spread

• The Guardians are favored by 1.5 runs at home versus the Royals. The Guardians are +162 to cover the spread, while the Royals are -196.

Guardians vs Royals Over/Under

• Guardians versus Royals, on Sept. 9, has an over/under of 7.5, with the over being -112 and the under -108.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have been chosen as favorites in 56 games this year and have walked away with the win 35 times (62.5%) in those games.
• This season Cleveland has been victorious 23 times in 32 chances when named as a favorite of at least -126 on the moneyline.
• The Guardians' games have gone over the total in 63 of their 140 opportunities.
• The Guardians are 74-66-0 against the spread in their 140 games with a line set by sportsbooks this season.
• The Royals have won 37 of the 80 games they were the underdog on the moneyline this season (46.2%).
• Kansas City has a record of 21-31 when playing as a moneyline underdog with odds of +108 or longer (40.4%).
• The Royals have played in 142 games with an over/under set, and have combined with opponents to go over the total 60 times (60-80-2).
• The Royals have collected a 70-72-0 record ATS this season (covering 49.3% of the time).

Guardians Player Leaders

• Jose Ramirez has 148 hits and an OBP of .357, both of which are best among Cleveland hitters this season. He has a .283 batting average and a slugging percentage of .501.
• Among qualifying hitters in the majors, his batting average ranks 19th, his on-base percentage ranks 24th, and he is 19th in slugging.
• Ramirez will look for his sixth straight game with a hit in this contest. During his last five outings he is batting .400 with two doubles, a triple, a home run, a walk and five RBIs.
• Steven Kwan has an OPS of .716, fueled by an OBP of .336 and a team-best slugging percentage of .381 this season. He's batting .277.
• Among qualifying batters, he ranks 28th in batting average, 60th in on-base percentage and 127th in slugging percentage.
• Kwan enters this matchup looking to extend his four-game hit streak. During his last five outings he is batting .350 with four walks and four RBIs.
• Kyle Manzardo has 97 hits this season and has a slash line of .239/.323/.470.
• Manzardo takes a two-game hitting streak into this game. During his last five outings he is hitting .375 with a double, a home run, four walks and four RBIs.
• Angel Martinez has been key for Cleveland with 91 hits, an OBP of .264 plus a slugging percentage of .358.

Royals Player Leaders

• Bobby Witt Jr. has a team-high slugging percentage (.503) while leading the Royals in hits (160). He's batting .294 and with an on-base percentage of .352.
• He ranks 10th in batting average, 34th in on-base percentage and 18th in slugging percentage among all qualified hitters in the majors.
• Maikel Garcia has a .357 OBP to pace his team. He has a batting average of .292 while slugging .469.
• He is 12th in batting average, 24th in on-base percentage and 43rd in slugging percentage in MLB.
• Vinnie Pasquantino has 24 doubles, a triple, 29 home runs and 44 walks while batting .260.
• Salvador Perez has 33 doubles, 25 home runs and 23 walks while batting .237.

Guardians vs Royals Head to Head

• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/26/2025: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/12/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/11/2025: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 6-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 3/29/2025: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 3/27/2025: 7-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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