Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for July 29

Odds updated as of 2:12 a.m.

The Cleveland Guardians will face the Cincinnati Reds in MLB action on Wednesday.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Reds Game Info

• Cleveland Guardians (55-54) vs. Cincinnati Reds (50-56)
• Date: Wednesday, July 29, 2026
• Time: 7:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and CleGuardians.TV

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | CIN: (+108)
• Spread: CLE: -1.5 (+130) | CIN: +1.5 (-156)
• Total: 9 -- Over: (-102) | Under: (-120)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 8-6, 4.02 ERA vs Brady Singer (Reds) - 5-9, 4.53 ERA

The Guardians will give the nod to Joey Cantillo (8-6, 4.02 ERA), who is eyeing win No. 9 on the season, and the Reds will counter with Brady Singer (5-9, 4.53 ERA). Cantillo and his team have a record of 14-8-0 against the spread when he starts. Cantillo's team has won 62.5% of his starts when they are favored on the moneyline (5-3). The Reds have gone 12-7-0 against the spread when Singer starts. The Reds are 7-10 in Singer's 17 starts this season that they were the moneyline underdog.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (52.8%)

Guardians vs Reds Moneyline

• Cincinnati is the underdog, +108 on the moneyline, while Cleveland is a -126 favorite despite being on the road.

Guardians vs Reds Spread

• The Guardians are at the Reds and are favored by 1.5 runs (+130 to cover) on the runline. Cincinnati is -156 to cover.

Guardians vs Reds Over/Under

• The over/under for Guardians-Reds on July 29 is 9. The over is -102, and the under is -120.

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Guardians vs Reds Betting Trends

• The Guardians have been favorites in 54 games this season and have come away with the win 27 times (50%) in those contests.
• This season Cleveland has come away with a win 13 times in 32 chances when named as a favorite of at least -126 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 49 of their 103 opportunities.
• The Guardians are 50-53-0 against the spread in their 103 games with a line set by sportsbooks this season.
• The Reds have compiled a 34-37 record in games they were listed as the moneyline underdog (winning 47.9% of those games).
• Cincinnati is 20-26 (winning 43.5% of its games) when it has played as a moneyline underdog of +108 or longer.
• In the 104 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 56 times (56-47-1).
• The Reds have a 57-47-0 record against the spread this season (covering 54.8% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 95 hits, batting .279 this season with 32 extra-base hits. He has an on-base percentage of .347 and a slugging percentage of .441.
• Among qualifying hitters in the majors, his batting average ranks 31st, his on-base percentage ranks 51st, and he is 62nd in slugging.
• Brayan Rocchio leads Cleveland in slugging percentage (.394) thanks to 27 extra-base hits. He's batting .266 with an on-base percentage of .328.
• He ranks 54th in batting average, 80th in on-base percentage and 108th in slugging in MLB.
• Jose Ramirez is batting .235 with a .399 slugging percentage and 35 RBI this year.
• Steven Kwan leads Cleveland in OBP (.348) this season, fueled by 83 hits.

Reds Player Leaders

• Sal Stewart has accumulated a slugging percentage of .475, a team-best for the Reds. He's batting .254 with an on-base percentage of .332.
• Including all the qualifying hitters in MLB, he is 76th in batting average, 73rd in on-base percentage and 36th in slugging percentage.
• Elly De La Cruz's 96 hits and .351 OBP both pace his team. He has a batting average of .277 while slugging .499.
• Including all qualifying hitters, his batting average puts him 37th, his on-base percentage is 43rd, and he is 20th in slugging.
• JJ Bleday has 11 doubles, a triple, 18 home runs and 44 walks while batting .231.
• Nathaniel Lowe is hitting .257 with 14 doubles, 12 home runs and 26 walks.

Guardians vs Reds Head to Head

• 7/28/2026: 2-0 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/28/2026: 6-5 CLE (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/17/2026: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/16/2026: 7-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)

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