Guardians vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 25

Odds updated as of 5:14 a.m.

The Friday schedule in MLB includes a matchup between the Cleveland Guardians and the Boston Red Sox.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Red Sox Game Info

• Cleveland Guardians (14-10) vs. Boston Red Sox (14-13)
• Date: Friday, April 25, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Apple TV+

Guardians vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-108) | BOS: (-108)
• Spread: CLE: +1.5 (-182) | BOS: -1.5 (+150)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Guardians vs Red Sox Probable Starting Pitchers

Probable Pitchers: Ben Lively (Guardians) - 1-2, 3.86 ERA vs Tanner Houck (Red Sox) - 0-2, 7.66 ERA

The Guardians will give the nod to Ben Lively (1-2, 3.86 ERA), who is eyeing win No. 2 on the season, and the Red Sox will turn to Tanner Houck (0-2, 7.66 ERA). Lively and his team have a record of 2-3-0 against the spread when he starts. Lively's team won his only start as a favorite this season. The Red Sox have a 1-4-0 ATS record in Houck's five starts with a set spread. The Red Sox were the underdog on the moneyline for two Houck starts this season -- they split the games.

Guardians vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (51.1%)

Guardians vs Red Sox Moneyline

• Looking at the moneyline for Guardians-Red Sox, Cleveland is the favorite at -108, and Boston is -108 playing on the road.

Guardians vs Red Sox Spread

Guardians vs Red Sox Over/Under

• The over/under for Guardians-Red Sox on April 25 is 8.5. The over is -120, and the under is -102.

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Guardians vs Red Sox Betting Trends

• The Guardians have been favorites in 10 games this season and have come away with the win eight times (80%) in those contests.
• Cleveland has a record of 8-2 in contests when oddsmakers favor them by -108 or more on the moneyline.
• The Guardians and their opponents have gone over the total this season in 12 of their 24 opportunities.
• The Guardians are 11-13-0 against the spread in their 24 games with a line set by sportsbooks this season.
• The Red Sox have won 42.9% of the games this season they were the underdog on the moneyline (3-4).
• Boston has gone 3-4 when playing as a moneyline underdog with odds of -108 or longer (42.9%).
• The Red Sox have played in 27 games with an over/under set, and have combined with their opponents to go over the total 11 times (11-14-2).
• The Red Sox have put together a 13-14-0 record ATS this season.

Guardians Player Leaders

• Steven Kwan leads Cleveland with an OBP of .394, plus a team-best slugging percentage of .495. He's batting .337 on the season.
• He ranks seventh in batting average, 20th in on-base percentage, and 33rd in slugging among all qualified hitters in baseball.
• Kwan hopes to build on a seven-game hitting streak in this matchup. During his last 10 outings he is batting .350 with two doubles, two home runs, four walks and six RBI.
• Jose Ramirez is hitting .265 with four doubles, five home runs and nine walks, while slugging .494 with an on-base percentage of .330.
• He is 64th in batting average, 77th in on-base percentage and 34th in slugging among qualified hitters.
• Kyle Manzardo leads Cleveland with 16 hits. He is batting .219 this season and 11 of his hits have gone for extra bases.
• Manzardo has logged a hit or more in six straight games. During his last 10 games he is batting .212 with two doubles, three home runs, five walks and seven RBI.
• Gabriel Arias has been key for Cleveland with 20 hits, an OBP of .321 plus a slugging percentage of .486.

Red Sox Player Leaders

• Alexander David Bregman has racked up a team-high OBP (.393) and slugging percentage (.563), while pacing the Red Sox in hits (33, while batting .320).
• Including all qualifying hitters in the big leagues, he ranks 15th in batting average, 22nd in on-base percentage and 15th in slugging percentage.
• Bregman brings a five-game hitting streak into this game. In his last five games he is hitting .444 with three doubles, a home run, three walks and five RBI.
• Wilyer Abreu is batting .271 with six doubles, four home runs and 16 walks. He's slugging .482 with an on-base percentage of .386.
• He is currently 55th in batting average, 28th in on-base percentage and 39th in slugging percentage among all qualified hitters.
• Jarren Duran has seven doubles, two triples, a home run and eight walks while hitting .250.
• Trevor Story is hitting .297 with two doubles, five home runs and four walks.

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