Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 16

Odds updated as of 2:12 a.m.

In MLB action on Thursday, the Cleveland Guardians take on the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs Orioles Game Info

• Cleveland Guardians (10-9) vs. Baltimore Orioles (9-9)
• Date: Thursday, April 16, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and MASN

Guardians vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | BAL: (+108)
• Spread: CLE: -1.5 (+168) | BAL: +1.5 (-205)
• Total: 8 -- Over: (-106) | Under: (-114)

Guardians vs Orioles Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 2-0, 0.51 ERA vs Shane Baz (Orioles) - 0-1, 4.50 ERA

The Guardians will look to Parker Messick (2-0) against the Orioles and Shane Baz (0-1). Messick and his team have covered in each of the three games he's started with a spread this season. This will be Messick's first start this season with his team as the moneyline favorite. The Orioles have a 1-2-0 record against the spread in Baz's starts. The Orioles were the moneyline underdog for one Baz start this season -- they lost.

Guardians vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59.2%)

Guardians vs Orioles Moneyline

• Baltimore is the underdog, +108 on the moneyline, while Cleveland is a -126 favorite at home.

Guardians vs Orioles Spread

• The Orioles are +1.5 on the spread (-205 to cover), and Cleveland is +168 to cover the runline.

Guardians vs Orioles Over/Under

• The over/under for Guardians-Orioles on April 16 is 8. The over is -106, and the under is -114.

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Guardians vs Orioles Betting Trends

• The Guardians have come away with two wins in the four contests they have been listed as the favorites in this season.
• Cleveland has played as a favorite of -126 or more just one time this year and came away with a loss in that game.
• The Guardians' games have gone over the total in nine of their 19 opportunities.
• The Guardians have an against the spread mark of 11-8-0 in 19 games with a line this season.
• The Orioles have won one of the four games they were the moneyline underdog this season (25%).
• Baltimore has not yet played a game with moneyline odds of +108 or longer.
• The Orioles have had an over/under set by oddsmakers 18 times, and have combined with opponents to go over the total in 10 of those games (10-8-0).
• The Orioles have covered only 38.9% of their games this season, going 7-11-0 against the spread.

Guardians Player Leaders

• Chase DeLauter has 15 hits, which is best among Cleveland hitters this season, while batting .259 with nine extra-base hits. He has an on-base percentage of .343 and a slugging percentage of .586.
• Among qualified batters, he ranks 71st in batting average, his on-base percentage ranks 75th, and he is 12th in slugging.
• Jose Ramirez is batting .205 with four doubles, three home runs and 10 walks. He's slugging .384 with an on-base percentage of .301.
• He ranks 139th in batting average, 129th in on-base percentage and 97th in slugging among qualifying hitters.
• Angel Martinez leads Cleveland with an OBP of .362 this season while batting .302 with three walks and eight runs scored.
• Steven Kwan leads Cleveland in slugging percentage (.324) thanks to four extra-base hits.

Orioles Player Leaders

• Gunnar Henderson has collected 17 hits, a team-best for the Orioles. He's batting .221 and slugging .519 with an on-base percentage of .302.
• Including all qualified players in the big leagues, he ranks 120th in batting average, 128th in on-base percentage and 33rd in slugging percentage.
• Taylor Ward paces his team with a .388 OBP, and has a club-best .438 slugging percentage. He has a batting average of .301.
• Including all qualified players, he ranks 31st in batting average, 24th in on-base percentage and 71st in slugging percentage.
• Jeremiah Jackson has two doubles and four home runs while hitting .340.
• Pete Alonso is batting .197 with four doubles, two home runs and 13 walks.

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