Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 29

Odds updated as of 1:11 p.m.

The Sunday schedule in MLB includes a matchup between the Cleveland Guardians and the Houston Astros.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Astros Game Info

• Cleveland Guardians (92-69) vs. Houston Astros (88-73)
• Date: Sunday, September 29, 2024
• Time: 3:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: BSGL

Guardians vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-154) | HOU: (+130)
• Spread: CLE: -1.5 (+146) | HOU: +1.5 (-176)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Guardians vs Astros Probable Starting Pitchers

Probable Pitchers: Nick Sandlin (Guardians) - 8-0, 3.75 ERA vs Ryan Gusto (Astros) - 0-0, 0.00 ERA

This contest's pitching matchup is set, as the Guardians will send Nick Sandlin (8-0) to the mound, while Ryan Gusto will answer the bell for the Astros. Sandlin helped his team cover the spread in his only opportunity this season as a starter. This will be Sandlin's first game as the moneyline favorite this season. Gusto and his team were underdogs on the moneyline each game he pitched a season ago.

Guardians vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (52.7%)

Guardians vs Astros Moneyline

• Cleveland is the favorite, -154 on the moneyline, while Houston is a +130 underdog on the road.

Guardians vs Astros Spread

• The Astros are at the Guardians, and are +1.5 on the runline. The Astros are +146 to cover the spread, and the Guardians are -176.

Guardians vs Astros Over/Under

• An over/under of 7.5 has been set for Guardians-Astros on Sept. 29, with the over being -106 and the under -114.

Bet on Cleveland Guardians vs. Houston Astros on FanDuel today!

Guardians vs Astros Betting Trends

• The Guardians have won in 63, or 64.9%, of the 97 contests they have been named as odds-on favorites in this year.
• This year Cleveland has won 20 of 29 games when listed as at least -154 on the moneyline.
• The Guardians and their opponents have hit the over in 70 of their 159 games with a total set by oddsmakers this season.
• In 159 games with a line this season, the Guardians have a mark of 85-74-0 against the spread.
• The Astros have been the underdog on the moneyline 43 total times this season. They've gone 21-22 in those games.
• Houston has played as a moneyline underdog of +130 or longer in just two games this season, which it lost both.
• In the 161 games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 65 times (65-90-6).
• The Astros have covered 49.7% of their games this season, going 80-81-0 ATS.

Guardians Player Leaders

• Jose Ramirez has 173 hits to go with a slugging percentage of .537, both of which are best among Cleveland hitters this season. He has a .279 batting average and an on-base percentage of .335.
• Among qualified hitters, he ranks 27th in batting average, his on-base percentage ranks 42nd, and he is 10th in slugging.
• Josh Naylor has 27 doubles, 31 home runs and 58 walks. He's batting .243 and slugging .456 with an on-base percentage of .320.
• Among all qualifying hitters, he ranks 97th in batting average, 79th in on-base percentage and 40th in slugging percentage.
• Steven Kwan leads Cleveland in OBP (.368) this season, fueled by 140 hits.
• Andres Gimenez has been key for Cleveland with 147 hits, an OBP of .298 plus a slugging percentage of .340.

Astros Player Leaders

• Yordan Alvarez has racked up 170 hits with a .392 on-base percentage, leading the Astros in both categories. He's batting .308 and slugging .567.
• He is sixth in batting average, fourth in on-base percentage and fifth in slugging percentage among all qualifying hitters in the big leagues.
• Jose Altuve leads his team with a .439 slugging percentage. He has a batting average of .295 with an on-base percentage of .350.
• Including all qualified players, he ranks ninth in batting average, 25th in on-base percentage and 57th in slugging percentage.
• Alex Bregman is batting .260 with 30 doubles, two triples, 26 home runs and 44 walks.
• Yainer Diaz is batting .299 with 29 doubles, three triples, 16 home runs and 24 walks.

Guardians vs Astros Head to Head

• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/1/2024: 3-2 CLE (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/30/2024: 10-9 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/2/2023: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/1/2023: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/31/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/11/2023: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2023: 6-4 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)

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