Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 3:11 p.m.

The Saturday slate in MLB includes a matchup between the Cleveland Guardians and the Houston Astros.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Astros Game Info

• Cleveland Guardians (92-68) vs. Houston Astros (87-73)
• Date: Saturday, September 28, 2024
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: BSGL

Guardians vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-120) | HOU: (+102)
• Spread: CLE: +1.5 (-215) | HOU: -1.5 (+176)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Guardians vs Astros Probable Starting Pitchers

Probable Pitchers: Ben Lively (Guardians) - 13-9, 3.80 ERA vs Justin Verlander (Astros) - 4-6, 5.55 ERA

The Guardians will call on Ben Lively (13-9) versus the Astros and Justin Verlander (4-6). Lively's team is 17-10-0 against the spread this season in his starts. When Lively starts a game and his team is the favorite on the moneyline, they have a record of 14-2. The Astros have gone 6-10-0 ATS in Verlander's 16 starts that had a set spread. The Astros are 1-3 in Verlander's four starts this season that they were the moneyline underdog.

Guardians vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (52.4%)

Guardians vs Astros Moneyline

• Houston is a +102 underdog on the moneyline, while Cleveland is a -120 favorite at home.

Guardians vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Guardians. The Astros are +176 to cover, while the Guardians are -215 to cover as a 1.5-run underdog on the runline.

Guardians vs Astros Over/Under

• An over/under of 8.5 has been set for Guardians-Astros on Sept. 28, with the over being -102 and the under -120.

Bet on Cleveland Guardians vs. Houston Astros on FanDuel today!

Guardians vs Astros Betting Trends

• The Guardians have been chosen as favorites in 96 games this year and have walked away with the win 63 times (65.6%) in those games.
• Cleveland has a record of 55-24 when favored by -120 or more this year.
• The Guardians and their opponents have gone over the total this season in 70 of their 158 opportunities.
• The Guardians have posted a record of 85-73-0 against the spread this season.
• The Astros have won 47.6% of the games this season they were the underdog on the moneyline (20-22).
• In games it has played as a moneyline underdog with odds of +102 or longer, Houston has gone 10-10 (50%).
• The Astros have had an over/under set by oddsmakers 160 times, and have combined with opponents to go over the total in 65 of those games (65-89-6).
• The Astros have covered 49.4% of their games this season, going 79-81-0 ATS.

Guardians Player Leaders

• Jose Ramirez leads Cleveland with 171 hits and a team-best slugging percentage of .530. He's batting .277 with an on-base percentage of .334.
• Among qualifying hitters in MLB, his batting average ranks 29th, his on-base percentage ranks 43rd, and he is 11th in slugging.
• Josh Naylor has 27 doubles, 31 home runs and 58 walks. He's batting .242 and slugging .456 with an on-base percentage of .318.
• Among qualifying hitters, he is 96th in batting average, 83rd in on-base percentage and 40th in slugging percentage.
• Steven Kwan has 140 hits this season and a team-best OBP of .368.
• Andres Gimenez has nine home runs, 63 RBI and a batting average of .252 this season.

Astros Player Leaders

• Yordan Alvarez has racked up 170 hits with a .392 on-base percentage, leading the Astros in both categories. He's batting .308 and slugging .567.
• Including all qualified hitters in the majors, he is sixth in batting average, fourth in on-base percentage and fifth in slugging percentage.
• Jose Altuve paces his team with a .439 slugging percentage. He has a batting average of .295 with an on-base percentage of .350.
• He is currently 10th in batting average, 26th in on-base percentage and 58th in slugging percentage among all qualified batters.
• Alex Bregman is hitting .260 with 30 doubles, two triples, 26 home runs and 44 walks.
• Yainer Diaz has 29 doubles, three triples, 16 home runs and 24 walks while batting .299.

Guardians vs Astros Head to Head

• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/1/2024: 3-2 CLE (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/30/2024: 10-9 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/2/2023: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/1/2023: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/31/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/11/2023: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2023: 6-4 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/9/2023: 10-9 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)

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