Guardians vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 6

Odds updated as of 6:11 p.m.

The Houston Astros will face the Cleveland Guardians in MLB action on Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this game.

Astros vs Guardians Game Info

• Houston Astros (34-28) vs. Cleveland Guardians (33-28)
• Date: Friday, June 6, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and SCHN

Astros vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-130) | CLE: (+110)
• Spread: HOU: -1.5 (+132) | CLE: +1.5 (-160)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Colton Gordon (Astros) - 0-1, 5.95 ERA vs Logan Allen (Guardians) - 3-3, 4.22 ERA

The probable starters are Colton Gordon (0-1) for the Astros and Logan Allen (3-3) for the Guardians. Gordon's team is 2-2-0 against the spread this season in his starts. Gordon's team is 1-1 this season when he starts and they're favored on the moneyline. When Allen starts, the Guardians are 3-6-0 against the spread. The Guardians have been the underdog on the moneyline in six of Allen's starts this season, and they went 2-4 in those games.

Astros vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55%)

Astros vs Guardians Moneyline

• Looking at the moneyline for Guardians-Astros, Cleveland is the underdog at +110, and Houston is -130 playing on the road.

Astros vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Astros. The Guardians are -160 to cover the spread, and the Astros are +132.

Astros vs Guardians Over/Under

• The over/under for Astros-Guardians on June 6 is 8.5. The over is -100, and the under is -122.

Bet on Houston Astros vs. Cleveland Guardians on FanDuel today!

Astros vs Guardians Betting Trends

• The Astros have won in 22, or 53.7%, of the 41 contests they have been named as odds-on favorites in this year.
• Houston has a record of 15-10 when favored by -130 or more this year.
• The Astros and their opponents have gone over the total this season in 24 of their 61 opportunities.
• The Astros are 32-29-0 against the spread in their 61 games with a line set by sportsbooks this season.
• The Guardians have been the moneyline underdog 37 total times this season. They've finished 18-19 in those games.
• Cleveland is 7-12 (winning just 36.8% of its games) when playing as a moneyline underdog of +110 or longer.
• The Guardians have played in 59 games with a set over/under, and have combined with opponents to go over the total 27 times (27-30-2).
• The Guardians have covered 49.2% of their games this season, going 29-30-0 against the spread.

Astros Player Leaders

• Jeremy Pena leads Houston with 75 hits and an OBP of .378, plus a team-best slugging percentage of .492. He's batting .318.
• Among all qualifying hitters in baseball, his batting average ranks ninth, his on-base percentage ranks 24th, and he is 28th in slugging.
• Pena hopes to build on an 11-game hitting streak in this matchup. In his last 10 outings he is hitting .425 with four doubles, three home runs, three walks and six RBIs.
• Isaac Paredes has seven doubles, a triple, 14 home runs and 31 walks. He's batting .252 and slugging .474 with an on-base percentage of .347.
• Among all qualifying players, he is 92nd in batting average, 53rd in on-base percentage and 47th in slugging percentage.
• Jose Altuve is batting .264 with a .404 slugging percentage and 23 RBI this year.
• Altuve takes a three-game hitting streak into this game. In his last five games he is hitting .278 with a walk and an RBI.
• Jake Meyers has three home runs, 16 RBI and a batting average of .287 this season.

Guardians Player Leaders

• Jose Ramirez has an on-base percentage of .384, a slugging percentage of .549, and has 74 hits, all club-bests for the Guardians (while batting .330).
• Including all the qualified hitters in the majors, his batting average is fourth, his on-base percentage ranks 15th, and he is 11th in slugging.
• Ramirez takes a five-game hitting streak into this game. During his last five outings he is batting .450 with a double, two home runs, two walks and two RBIs.
• Steven Kwan is hitting .306 with 13 doubles, five home runs and 20 walks. He's slugging .426 with an on-base percentage of .367.
• Including all qualifying hitters, he ranks 13th in batting average, 31st in on-base percentage and 76th in slugging percentage.
• Carlos Santana has six doubles, seven home runs and 31 walks while batting .261.
• Kyle Manzardo is batting .210 with six doubles, two triples, 11 home runs and 23 walks.

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