Guardians vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for April 6

Odds updated as of 3:12 p.m.

MLB action on Sunday includes the Cleveland Guardians playing the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Guardians vs Angels Game Info

• Cleveland Guardians (3-5) vs. Los Angeles Angels (5-3)
• Date: Sunday, April 6, 2025
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and CLEG

Guardians vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-148) | LAA: (+126)
• Spread: CLE: -1.5 (+112) | LAA: +1.5 (-134)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Guardians vs Angels Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 0-1, 13.50 ERA vs Ian Anderson (Angels) - 0-1, 11.25 ERA

The Guardians will look to Luis Ortiz (0-1) against the Angels and Ian Anderson (0-1). Ortiz and his team failed to cover the spread in his only opportunity this season as a starter. This will be Ortiz's first start this season with his team as the moneyline favorite. Anderson and his team were moneyline underdogs every time he pitched a season ago.

Guardians vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55.5%)

Guardians vs Angels Moneyline

• The moneyline numbers for Guardians vs. Angels reveal Cleveland as the favorite (-148) and Los Angeles as the underdog (+126) despite being the home team.

Guardians vs Angels Spread

• The Angels are hosting the Guardians, and are +1.5 on the runline. The Angels are +112 to cover the spread, and the Guardians are -134.

Guardians vs Angels Over/Under

• A combined run total of 8.5 has been set for Guardians-Angels on April 6, with the over at -118 and the under at -104.

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Guardians vs Angels Betting Trends

• The Guardians have split the two games they have played as odds-on favorites this season.
• Cleveland has played as a favorite of -148 or more just one time this year and came away with a loss in that game.
• The Guardians and their opponents have hit the over in five of their eight games with a total set by oddsmakers this season.
• The Guardians have posted a record of 3-5-0 against the spread this season.
• The Angels have won 60% of the games this season they were the moneyline underdog (3-2).
• Los Angeles has played as a moneyline underdog of +126 or longer in just one game this season, which it won.
• The Angels have had an over/under set by bookmakers eight times, and have combined with opponents to go over the total in six of those games (6-2-0).
• The Angels have a 3-5-0 record against the spread this season (covering just 37.5% of the time).

Guardians Player Leaders

• Jose Ramirez has eight hits and an OBP of .429, both of which are tops among Cleveland hitters this season. He has a .348 batting average and a slugging percentage of .957.
• Among qualifying batters in MLB, his batting average ranks 19th, his on-base percentage ranks 21st, and he is fourth in slugging.
• Kyle Manzardo is batting .259 with a double, a triple, two home runs and four walks, while slugging .593 with an on-base percentage of .333.
• He is 73rd in batting average, 81st in on-base percentage and 33rd in slugging in the major leagues.
• Manzardo has picked up at least one hit in two straight games. During his last five outings he is hitting .125 with a walk and two RBI.
• Steven Kwan has an OPS of .924, fueled by an OBP of .424 and a team-best slugging percentage of .500 this season.
• Kwan brings a four-game hitting streak into this game. During his last five outings he is batting .278 with two walks.
• Carlos Santana is batting .290 with a .343 OBP and three RBI for Cleveland this season.
• Santana brings a three-game hitting streak into this matchup. In his last five games he is batting .368 with a double, a home run, two walks and two RBI.

Angels Player Leaders

• Mike Trout is batting .172 with a double, three home runs and four walks. He's slugging .517 with an on-base percentage of .278.
• Including all the qualifying hitters in the majors, he is 153rd in batting average, 129th in on-base percentage and 52nd in slugging percentage.
• Trout brings a four-game hitting streak into this game. During his last five outings he is hitting .211 with a double, three home runs, three walks and eight RBI.
• Logan O'Hoppe's eight hits pace his team. He has a batting average of .320 while slugging .800 with an on-base percentage of .346.
• His batting average is 31st among all qualified players, his on-base percentage ranks 76th, and he is sixth in slugging.
• Kyren Paris has a triple, a home run and three walks while hitting .429.
• Nolan Schanuel paces his team with a .387 slugging percentage.

Guardians vs Angels Head to Head

• 4/5/2025: 10-4 LAA (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/4/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/25/2024: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/24/2024: 10-4 CLE (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/5/2024: 4-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/4/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/3/2024: 6-0 LAA (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/10/2023: 2-1 LAA (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/9/2023: 6-2 LAA (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -146, Underdog Moneyline: +124)

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