Giants vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 6:11 a.m.

In MLB action on Friday, the San Francisco Giants take on the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Giants vs White Sox Game Info

• San Francisco Giants (44-37) vs. Chicago White Sox (26-55)
• Date: Friday, June 27, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and NBCS-BA

Giants vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-166) | CHW: (+140)
• Spread: SF: -1.5 (+104) | CHW: +1.5 (-125)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Giants vs White Sox Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 5-5, 3.79 ERA vs Aaron Civale (White Sox) - 1-4, 5.03 ERA

The Giants will look to Landen Roupp (5-5) versus the White Sox and Aaron Civale (1-4). Roupp's team is 5-10-0 against the spread in his starts this season. When Roupp starts a game and his team is the favorite on the moneyline, they have a record of 4-2. The White Sox have gone 3-4-0 ATS in Civale's seven starts with a set spread. The White Sox have been the underdog on the moneyline in five of Civale's starts this season, and they went 1-4 in those games.

Giants vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (60.3%)

Giants vs White Sox Moneyline

• Looking at the moneyline for Giants-White Sox, San Francisco is the favorite at -166, and Chicago is +140 playing at home.

Giants vs White Sox Spread

• The White Sox are hosting the Giants, and are +1.5 on the runline. The White Sox are +104 to cover the spread, and the Giants are -125.

Giants vs White Sox Over/Under

• A total of 8.5 runs has been set for the Giants-White Sox contest on June 27, with the over available at -110 and the under at -110.

Bet on San Francisco Giants vs. Chicago White Sox on FanDuel today!

Giants vs White Sox Betting Trends

• The Giants have come away with 30 wins in the 54 contests they have been listed as the favorites in this season.
• This season San Francisco has been victorious seven times in 14 chances when named as a favorite of at least -166 on the moneyline.
• The Giants and their opponents have gone over in 37 of their 81 games with a total set by sportsbooks this season.
• The Giants are 35-46-0 against the spread in their 81 games that had a posted line this season.
• The White Sox have won 24 of the 77 games they were listed as the moneyline underdog this season (31.2%).
• Chicago has gone 14-36 when it has played as a moneyline underdog with odds of +140 or longer (28%).
• The White Sox have had an over/under set by bookmakers 78 times, and have combined with opponents to go over the total in 36 of those games (36-38-4).
• The White Sox have covered 55.1% of their games this season, going 43-35-0 against the spread.

Giants Player Leaders

• Rafael Devers leads San Francisco with 83 hits and an OBP of .396 this season. He has a .270 batting average and a slugging percentage of .502.
• Among qualified hitters in MLB, his batting average ranks 56th, his on-base percentage ranks fourth, and he is 23rd in slugging.
• Jung Hoo Lee is hitting .252 with 17 doubles, six triples, six home runs and 29 walks. He's slugging .412 with an on-base percentage of .322.
• He ranks 93rd in batting average, 94th in on-base percentage and 93rd in slugging among qualified hitters.
• Heliot Ramos has an OPS of .825, fueled by an OBP of .358 and a team-best slugging percentage of .467 this season.
• Wilmer Flores has 11 home runs, 54 RBI and a batting average of .243 this season.

White Sox Player Leaders

• Miguel Vargas has accumulated 67 hits with a .314 on-base percentage and a .422 slugging percentage, all club-bests for the White Sox. He's batting .233.
• Including all the qualified hitters in the majors, his batting average places him 128th, his on-base percentage is 109th, and he is 82nd in slugging.
• Andrew Benintendi is hitting .236 with nine doubles, two triples, nine home runs and 16 walks. He's slugging .445 with an on-base percentage of .297.
• Chase Meidroth is batting .264 with five doubles, two home runs and 27 walks.
• Luis Robert has eight doubles, eight home runs and 29 walks while batting .185.

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