Giants vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 8:11 p.m.

The MLB schedule on Friday includes the San Francisco Giants taking on the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Giants vs Cardinals Game Info

• San Francisco Giants (79-80) vs. St. Louis Cardinals (81-78)
• Date: Friday, September 27, 2024
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-164) | STL: (+138)
• Spread: SF: -1.5 (+130) | STL: +1.5 (-156)
• Total: 7 -- Over: (-102) | Under: (-120)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 1-1, 2.70 ERA vs Miles Mikolas (Cardinals) - 9-11, 5.35 ERA

The Giants will give the nod to Landen Roupp (1-1, 2.70 ERA), who is eyeing win No. 2 on the season, and the Cardinals will turn to Miles Mikolas (9-11, 5.35 ERA). Roupp and his team have covered in each of his three starts with a spread this season. Roupp has yet to start a game this season when his team was the moneyline favorite. The Cardinals have gone 17-14-0 ATS in Mikolas' 31 starts that had a set spread. The Cardinals are 12-10 in Mikolas' 22 starts this season that they were the moneyline underdog.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (58.6%)

Giants vs Cardinals Moneyline

• The Giants vs Cardinals moneyline has San Francisco as a -164 favorite, while St. Louis is a +138 underdog on the road.

Giants vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-156 to cover), and San Francisco is +130 to cover the runline.

Giants vs Cardinals Over/Under

• The Giants-Cardinals contest on Sept. 27 has been given an over/under of 7 runs. The over is set at -102 and the under at -120.

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Giants vs Cardinals Betting Trends

• The Giants have been favorites in 78 games this season and have come away with the win 44 times (56.4%) in those contests.
• This season San Francisco has been victorious 17 times in 24 chances when named as a favorite of at least -164 on the moneyline.
• The Giants and their opponents have gone over the total this season in 80 of their 157 opportunities.
• The Giants are 78-79-0 against the spread in their 157 games that had a posted line this season.
• The Cardinals have been the underdog on the moneyline 79 total times this season. They've gone 38-41 in those games.
• St. Louis has a 4-10 record (winning only 28.6% of its games) when playing as a moneyline underdog of +138 or longer.
• The Cardinals have combined with opponents to hit the over on the total 70 times this season for a 70-82-2 record against the over/under.
• The Cardinals have a 74-80-0 record against the spread this season (covering 48.1% of the time).

Giants Player Leaders

• Matt Chapman leads San Francisco with an OBP of .328, plus a team-best slugging percentage of .459. He's batting .246 on the season.
• He ranks 85th in batting average, 58th in on-base percentage, and 39th in slugging among all qualifying hitters in baseball.
• Heliot Ramos leads San Francisco with 127 hits. He is batting .273 this season and has 48 extra-base hits. He's also slugging .476 with an on-base percentage of .326.
• Among qualified hitters, he is 36th in batting average, 62nd in on-base percentage and 25th in slugging percentage.
• Ramos brings a three-game streak with at least one hit into this contest. During his last five outings he is batting .318 with a double, a home run, a walk and two RBI.
• Michael Conforto has collected 101 base hits, an OBP of .306 and a slugging percentage of .450 this season.
• Conforto has picked up a hit in four straight games. In his last five games he is hitting .238 with two doubles, two home runs, a walk and four RBI.
• Mike Yastrzemski has 18 home runs, 56 RBI and a batting average of .232 this season.
• Yastrzemski has safely hit in two straight games. During his last five outings he is hitting .190 with a double, a home run and three RBI.

Cardinals Player Leaders

• Brendan Donovan has put up a .338 on-base percentage and a .409 slugging percentage, both team-high numbers for the Cardinals. He's batting .274.
• Including all the qualifying hitters in the majors, his batting average is 33rd, his on-base percentage is 39th, and he is 78th in slugging.
• Alec Burleson has collected 142 hits to pace his team. He has a batting average of .265 while slugging .421 with an on-base percentage of .308.
• Including all qualified hitters, his batting average puts him 47th, his on-base percentage ranks 103rd, and he is 70th in slugging.
• Masyn Winn is hitting .267 with 30 doubles, five triples, 15 home runs and 40 walks.
• Nolan Arenado has 22 doubles, 16 home runs and 44 walks while batting .269.

Giants vs Cardinals Head to Head

• 6/23/2024: 5-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/22/2024: 9-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/20/2024: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/14/2023: 8-5 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/13/2023: 11-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/12/2023: 4-3 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/27/2023: 6-0 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/26/2023: 7-3 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/25/2023: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/24/2023: 4-0 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)

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