Duke vs Syracuse Basketball Prediction, Odds, Picks, Best Bets for February 5

The Duke Blue Devils (19-2, 11-0 ACC) hope to build on a five-game road winning streak when they visit the Syracuse Orange (10-12, 4-7 ACC) on February 5, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Syracuse Game Info and Odds

• Game day: Wednesday, February 5, 2025
• Game time: 7:00 PM ET
• TV channel: ESPN2
• Location: Syracuse, New York
• Arena: JMA Wireless Dome

Duke is a 17.5-point favorite over Syracuse on Wednesday and the total has been set at 143.5 points. Here's some betting trends and insights if you are planning on making a wager on the matchup.

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Duke vs. Syracuse: ATS Betting Stats and Trends

• Duke is 13-8-0 ATS this season.
• Syracuse has put together an 11-11-0 ATS record so far this year.
• Duke covers the spread when it is a 17.5-point favorite or more 54.5% of the time. That's more often than Syracuse covers as an underdog of 17.5 or more (never covered this season).
• At home, the Blue Devils own a worse record against the spread (8-5-0) compared to their ATS record in away games (5-1-0).
• This season, the Orange are 5-7-0 at home against the spread (.417 winning percentage). Away, they are 4-3-0 ATS (.571).
• Duke has covered the spread seven times in 11 conference games.
• Syracuse has beaten the spread seven times in 11 ACC games.

Duke vs. Syracuse: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 19 games this year and has walked away with the win 17 times (89.5%) in those games.
• The Blue Devils have yet to lose in 10 games when named as moneyline favorite of -3448 or better.
• Syracuse has won three of the 14 games it was the underdog on the moneyline this season (21.4%).
• The Orange have played as a moneyline underdog of +1280 or longer in only one game this season, which they lost.
• Duke has an implied victory probability of 97.2% according to the moneyline set for this matchup.

Duke vs. Syracuse Head-to-Head Comparison

• Duke outscores opponents by 20.3 points per game (scoring 80.3 per game to rank 49th in college basketball while allowing 60 per outing to rank fifth in college basketball) and has a +426 scoring differential overall.
• Cooper Flagg paces Duke, scoring 20 points per game (16th in the nation).
• Syracuse is being outscored by 2.8 points per game, with a -62 scoring differential overall. It puts up 74.2 points per game (192nd in college basketball), and allows 77 per contest (312th in college basketball).
• Eddie Lampkin Jr. is ranked 1029th in college basketball with a team-high 10.1 points per game.
• The Blue Devils are 19th in the country at 36.6 rebounds per game. That's 9.8 more than the 26.8 their opponents average.
• Flagg averages eight rebounds per game (ranking 69th in college basketball) to lead the Blue Devils.
• The Orange record 34.3 rebounds per game (73rd in college basketball) while conceding 32.1 per contest to opponents. They outrebound opponents by 2.2 boards per game.
• Lampkin's nine rebounds per game lead the Orange and rank 31st in the country.
• Duke ranks seventh in college basketball with 107.6 points scored per 100 possessions, and fourth in college basketball defensively with 80.4 points conceded per 100 possessions.
• The Orange rank 227th in college basketball with 94.1 points scored per 100 possessions, and 308th defensively with 97.6 points conceded per 100 possessions.

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