Duke vs Lipscomb College Basketball Prediction, Odds, Picks, Best Bets for Dec. 16

The Duke Blue Devils (10-0) will attempt to continue a 10-game winning streak when they host the Lipscomb Bisons (6-4) on December 16, 2025. The Bisons have won five games in a row.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Lipscomb Game Info and Odds

• Game day: Tuesday, December 16, 2025
• Game time: 6 p.m. ET
• TV channel: ACC Network
• Location: Durham, North Carolina
• Arena: Cameron Indoor Stadium

Duke vs. Lipscomb Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (94.7%)

Before making a bet on Tuesday's Duke-Lipscomb spread (Duke -33.5) or over/under (150.5 points), check out the betting trends and insights below.

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Duke vs. Lipscomb: ATS Betting Stats and Trends

• Duke has compiled a 6-4-0 record against the spread this season.
• Lipscomb has won six games against the spread this season, while failing to cover three times.
• Against the spread last year, the Blue Devils fared worse at home, covering 11 times in 17 home games, and nine times in 11 road games.
• The Bisons have the same winning percentage against the spread (.667) at home (2-1-0 record) and away (4-2-0) this year.

Duke vs. Lipscomb Head-to-Head Comparison

• On offense, Duke was the 11th-best team in the country (83.2 points per game) last year. On defense, it was seventh-best (62.8 points allowed per game).
• Duke was the 24th-best team in the country in rebounds per game (35.6) and 12th-best in rebounds conceded (27.3) last season.
• With 16.9 assists per game, Duke was 17th-best in the country last season.
• In terms of turnovers, Duke was ninth-best in the nation in committing them (8.9 per game) last year. It was 265th in forcing them (10.4 per game).
• Lipscomb averaged 78.6 points per game (64th-ranked in college basketball) last season, while allowing 67.7 points per contest (52nd-ranked).
• With 32.9 boards per game, Lipscomb was 127th in college basketball. It ceded 31.4 rebounds per contest, which ranked 195th in college basketball.
• Lipscomb ranked 74th in the country with 15.1 dimes per game.
• Lipscomb ranked 25th-best in the nation by committing only 9.3 turnovers per game. In terms of forced turnovers, it ranked 250th in college basketball (10.5 per contest).

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