Duke vs Arizona Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Sweet 16

The No. 4-seed Arizona Wildcats (24-12) head into a Sweet 16 matchup against the No. 1 Duke Blue Devils (33-3) on Thursday at 9:39 p.m. ET as the NCAA Tournament continues at Prudential Center airing on CBS.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Arizona Game Info and Odds

• Game day: Thursday, March 27, 2025
• Game time: 9:39 p.m. ET
• TV channel: CBS
• Location: Newark, New Jersey
• Arena: Prudential Center

Duke vs. Arizona Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (71.9%)

To help you make an informed wager on Duke-Arizona outing (in which Duke is a 9.5-point favorite and the over/under is set at 153.5 points), here are some betting insights and trends for Thursday's game.

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Duke vs. Arizona: ATS Betting Stats and Trends

• Duke has compiled a 24-12-0 ATS record so far this year.
• Arizona has won 18 games against the spread this year, while failing to cover 17 times.
• Against the spread, the Blue Devils have played worse at home, covering 11 times in 17 home games, and nine times in 11 road games.
• Against the spread, the Wildcats have been better at home (9-7-0) than on the road (6-5-0).

Duke vs. Arizona: Moneyline Betting Stats

• Duke has been the moneyline favorite in 34 games this season and has come away with the win 31 times (91.2%) in those contests.
• The Blue Devils have been a -490 moneyline favorite on 24 occasions this season and won every game.
• Arizona has won 44.4% of the games this season it was the underdog on the moneyline (4-5).
• The Wildcats have not yet played as a moneyline underdog of +365 or longer.
• The moneyline set for this matchup implies Duke has a 83.1% chance of coming away with a victory in the contest.

Duke vs. Arizona Head-to-Head Comparison

• Duke outscores opponents by 21.5 points per game (scoring 83.2 per game to rank 12th in college basketball while allowing 61.7 per outing to rank sixth in college basketball) and has a +774 scoring differential overall.
• Cooper Flagg paces Duke, averaging 18.7 points per game (56th in college basketball).
• Arizona has a +348 scoring differential, topping opponents by 9.7 points per game. It is putting up 82.2 points per game, 17th in college basketball, and is giving up 72.5 per outing to rank 197th in college basketball.
• Caleb Love's team-leading 16.8 points per game rank him 127th in college basketball.
• The 35.9 rebounds per game the Blue Devils average rank 19th in college basketball, and are 8.7 more than the 27.2 their opponents collect per contest.
• Flagg's 7.5 rebounds per game lead the Blue Devils and rank 103rd in college basketball action.
• The Wildcats win the rebound battle by 8.2 boards on average. They record 36.8 rebounds per game, 11th in college basketball, while their opponents grab 28.6.
• Tobe Awaka is 61st in the country with eight rebounds per game, leading the Wildcats.
• Duke averages 110.9 points per 100 possessions on offense (first in college basketball), and allows 82.2 points per 100 possessions (fourth in college basketball).
• The Wildcats score 102.1 points per 100 possessions (42nd in college basketball), while allowing 90.1 points per 100 possessions (86th in college basketball).

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