Dodgers vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 7:11 p.m.

The Los Angeles Dodgers versus the Chicago Cubs is on the MLB schedule for Tuesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Cubs Game Info

• Los Angeles Dodgers (16-7) vs. Chicago Cubs (14-10)
• Date: Tuesday, April 22, 2025
• Time: 7:40 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SportsNet LA

Dodgers vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-118) | CHC: (-100)
• Spread: LAD: -1.5 (+138) | CHC: +1.5 (-166)
• Total: 9 -- Over: (-104) | Under: (-118)

Dodgers vs Cubs Probable Starting Pitchers

Probable Pitchers: Dustin May (Dodgers) - 1-1, 1.06 ERA vs Shota Imanaga (Cubs) - 2-1, 2.22 ERA

The probable starters are Dustin May (1-1) for the Dodgers and Shota Imanaga (2-1) for the Cubs. When May starts, his team is 2-1-0 against the spread this season. May's team is 2-1 this season when he starts and they are the moneyline favorite. The Cubs have gone 2-3-0 ATS in Imanaga's five starts that had a set spread. The Cubs were the underdog on the moneyline for two Imanaga starts this season -- they split the games.

Dodgers vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (50.6%)

Dodgers vs Cubs Moneyline

• Los Angeles is the favorite, -118 on the moneyline, while Chicago is a -100 underdog despite being at home.

Dodgers vs Cubs Spread

• The Dodgers are favored by 1.5 runs on the road against the Cubs. The Dodgers are +138 to cover the spread, while the Cubs are -166.

Dodgers vs Cubs Over/Under

• The Dodgers-Cubs game on April 22 has been given an over/under of 9 runs. The over is set at -104 and the under at -118.

Bet on Los Angeles Dodgers vs. Chicago Cubs on FanDuel today!

Dodgers vs Cubs Betting Trends

• The Dodgers have been favorites in 21 games this season and have come away with the win 15 times (71.4%) in those contests.
• This year Los Angeles has won 15 of 21 games when listed as at least -118 on the moneyline.
• The Dodgers and their opponents have gone over the total this season in 11 of their 23 opportunities.
• The Dodgers have an against the spread mark of 11-12-0 in 23 games with a line this season.
• The Cubs are 6-6 in games they were the underdog on the moneyline (winning 50% of those games).
• When playing as a moneyline underdog with odds of -100 or longer, Chicago has gone 5-5 (50%).
• The Cubs have played in 23 games with an over/under set, and have combined with their opponents to go over the total 15 times (15-7-1).
• The Cubs have covered 56.5% of their games this season, going 13-10-0 against the spread.

Dodgers Player Leaders

• Tommy Edman leads Los Angeles with 23 hits and a team-best slugging percentage of .545. He's batting .261 with an on-base percentage of .298.
• He ranks 73rd in batting average, 115th in on-base percentage, and 20th in slugging among all qualified hitters in baseball.
• Shohei Ohtani leads the Dodgers with an OPS of .905. He has a slash line of .277/.375/.530 this season.
• He ranks 57th in batting average, 34th in on-base percentage and 24th in slugging in the majors.
• Markus Lynn Betts has 18 hits this season and has a slash line of .243/.356/.432.
• Teoscar Hernandez is batting .250 with a .274 OBP and 17 RBI for Los Angeles this season.

Cubs Player Leaders

• Kyle Tucker has put up a team-best OBP (.404) and slugging percentage (.615), while leading the Cubs in hits (29, while batting .302).
• He ranks 32nd in batting average, 16th in on-base percentage and ninth in slugging percentage among all qualified hitters in the big leagues.
• Carson Kelly is batting .371 with a double, a triple, six home runs and 12 walks. He's slugging .971 with an on-base percentage of .531.
• Michael Busch has six doubles, a triple, five home runs and six walks while hitting .316.
• Ian Happ is hitting .245 with four doubles, two home runs and 14 walks.

Dodgers vs Cubs Head to Head

• 4/13/2025: 4-2 CHC (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 4/12/2025: 16-0 CHC (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/11/2025: 3-0 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 3/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/18/2025: 4-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/11/2024: 10-8 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/10/2024: 6-3 CHC (Favorite: Dodgers, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/9/2024: 10-4 CHC (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/7/2024: 8-1 CHC (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/6/2024: 4-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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