Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 17

Odds updated as of 1:11 a.m.

On Saturday in MLB, the Chicago Cubs are up against the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs White Sox Game Info

• Chicago Cubs (26-19) vs. Chicago White Sox (14-31)
• Date: Saturday, May 17, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and CHSN

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-275) | CHW: (+225)
• Spread: CHC: -1.5 (-137) | CHW: +1.5 (+114)
• Total: 10.5 -- Over: (-100) | Under: (-122)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 3-2, 2.78 ERA vs Sean Burke (White Sox) - 2-4, 4.15 ERA

The Cubs will give the nod to Matthew Boyd (3-2) versus the White Sox and Sean Burke (2-4). Boyd and his team have a record of 2-6-0 against the spread when he starts. When Boyd starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The White Sox have a 6-2-0 ATS record in Burke's eight starts with a set spread. The White Sox have a 4-4 record in Burke's eight starts this season when they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (70%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -275 favorite, while the White Sox are a +225 underdog on the road.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -137 to cover, while the White Sox are +114 to cover.

Cubs vs White Sox Over/Under

• The Cubs-White Sox game on May 17 has been given an over/under of 10.5 runs. The over is set at -100 and the under at -122.

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Cubs vs White Sox Betting Trends

• The Cubs have been favorites in 23 games this season and have come away with the win 16 times (69.6%) in those contests.
• The Cubs have yet to enter a game this year with shorter moneyline odds than -275.
• The Cubs and their opponents have hit the over in 27 of their 43 games with a total this season.
• In 43 games with a line this season, the Cubs have a mark of 22-21-0 against the spread.
• The White Sox have been the underdog on the moneyline 43 total times this season. They've gone 13-30 in those games.
• The White Sox have a record of 1-2 when playing as a moneyline underdog with odds of +225 or longer (33.3%).
• The White Sox have combined with their opponents to hit the over on the total 20 times this season for a 20-22-2 record against the over/under.
• The White Sox have put together a 23-21-0 record against the spread this season.

Cubs Player Leaders

• Kyle Tucker has 47 hits this season and a team-best OBP of .372. He has a .267 batting average and a slugging percentage of .534.
• He is 59th in batting average, 30th in on-base percentage, and 14th in slugging among all qualified batters in baseball.
• Tucker hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .200 with a double, two triples, a walk and an RBI.
• Pete Crow-Armstrong has 49 hits to go with a slugging percentage of .563, both of which lead Chicago hitters this season. He's batting .282 with an on-base percentage of .319.
• He ranks 39th in batting average, 95th in on-base percentage and eighth in slugging in the major leagues.
• Crow-Armstrong has picked up at least one hit in three straight games. In his last five games he is hitting .421 with three home runs, a walk and nine RBIs.
• Seiya Suzuki has 41 hits this season and has a slash line of .246/.301/.521.
• Suzuki enters this game with two games in a row with at least one hit. In his last five games he is batting .211 with two doubles, two home runs, a walk and five RBIs.
• Carson Kelly is batting .299 with a .436 OBP and 23 RBI for Chicago this season.

White Sox Player Leaders

• Miguel Vargas has racked up 37 hits with a .326 on-base percentage, leading the White Sox in both categories. He's batting .242 and slugging .405.
• Including all the qualified hitters in the big leagues, his batting average places him 101st, his on-base percentage ranks 85th, and he is 85th in slugging.
• Luis Robert is batting .181 with three doubles, five home runs and 21 walks. He's slugging .306 with an on-base percentage of .283.
• He is currently 158th in batting average, 130th in on-base percentage and 153rd in slugging percentage among all qualifying hitters.
• Lenyn Sosa has a .373 slugging percentage, which leads the White Sox.
• Andrew Vaughn is hitting .185 with eight doubles, five home runs and seven walks.

Cubs vs White Sox Head to Head

• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/4/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -300, Underdog Moneyline: +245)
• 8/16/2023: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/15/2023: 5-3 CHW (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/26/2023: 10-7 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/25/2023: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/29/2022: 5-4 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)

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