Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 2:12 a.m.

The Chicago Cubs are among the MLB squads playing on Friday, versus the Cincinnati Reds.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Reds Game Info

• Chicago Cubs (88-65) vs. Cincinnati Reds (77-76)
• Date: Friday, September 19, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: MLB Network, FDSOH, and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-124) | CIN: (+106)
• Spread: CHC: -1.5 (+138) | CIN: +1.5 (-166)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Shota Imanaga (Cubs) - 9-7, 3.29 ERA vs Nick Lodolo (Reds) - 8-8, 3.30 ERA

This contest's pitching matchup is set, as the Cubs will send Shota Imanaga (9-7) to the mound, while Nick Lodolo (8-8) will answer the bell for the Reds. Imanaga and his team are 9-13-0 ATS this season when he starts. When Imanaga starts a game and his team is the favorite on the moneyline, they have a record of 9-6. The Reds have a 13-11-0 ATS record in Lodolo's 24 starts with a set spread. The Reds have been the moneyline underdog in 13 of Lodolo's starts this season, and they went 5-8 in those games.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (52.4%)

Cubs vs Reds Moneyline

• Chicago is the favorite, -124 on the moneyline, while Cincinnati is a +106 underdog despite being at home.

Cubs vs Reds Spread

• The Reds are +1.5 on the spread (-166 to cover), and Chicago is +138 to cover the runline.

Cubs vs Reds Over/Under

• The over/under for Cubs-Reds on Sept. 19 is 8.5. The over is -105, and the under is -115.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have won in 66, or 64.1%, of the 103 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 57-28 when favored by -124 or more this year.
• Contests with the Cubs have gone over the total set by sportsbooks in 68 of 149 chances this season.
• The Cubs have posted a record of 71-78-0 against the spread this season.
• The Reds have put together a 39-42 record in games they were the underdog on the moneyline (winning 48.1% of those games).
• When playing as a moneyline underdog with odds of +106 or longer, Cincinnati has a 26-33 record (winning 44.1% of its games).
• The Reds have played in 146 games with an over/under set, and have combined with opponents to go over the total 57 times (57-81-8).
• The Reds have put together a 75-71-0 record against the spread this season.

Cubs Player Leaders

• Nico Hoerner leads Chicago in slugging percentage (.399) thanks to 39 extra-base hits. He has a .301 batting average and an on-base percentage of .350.
• He ranks seventh in batting average, 37th in on-base percentage, and 103rd in slugging among qualifying hitters in baseball.
• Pete Crow-Armstrong is hitting .246 with 37 doubles, four triples, 29 home runs and 29 walks. He's slugging .481 with an on-base percentage of .287.
• Among all qualifying players, he is 98th in batting average, 136th in on-base percentage and 28th in slugging percentage.
• Ian Happ is batting .241 with a .422 slugging percentage and 73 RBI this year.
• Seiya Suzuki has been key for Chicago with 132 hits, an OBP of .324 plus a slugging percentage of .459.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .430 and has 156 hits, both team-best numbers for the Reds. He's batting .261 and with an on-base percentage of .332.
• He ranks 59th in batting average, 65th in on-base percentage and 73rd in slugging percentage among all qualified hitters in MLB.
• TJ Friedl's .362 OBP paces his team. He has a batting average of .257 while slugging .368.
• He is 75th in batting average, 17th in on-base percentage and 132nd in slugging percentage in the majors.
• Spencer Steer is batting .240 with 20 doubles, two triples, 18 home runs and 45 walks.
• Austin Hays is batting .269 with 16 doubles, five triples, 15 home runs and 29 walks.

Cubs vs Reds Head to Head

• 9/18/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/6/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 5-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2025: 3-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/31/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/25/2025: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/23/2025: 13-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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