Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 7:12 a.m.

The Friday schedule in MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Cubs vs Reds Game Info

• Chicago Cubs (30-20) vs. Cincinnati Reds (25-26)
• Date: Friday, May 23, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | CIN: (-102)
• Spread: CHC: -1.5 (+150) | CIN: +1.5 (-182)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 4-2, 2.98 ERA vs Hunter Greene (Reds) - 4-2, 2.36 ERA

The Cubs will call on Matthew Boyd (4-2) against the Reds and Hunter Greene (4-2). When Boyd starts, his team is 3-6-0 against the spread this season. Boyd's team has been victorious in 80% of the games he's started as the moneyline favorite with a record of 4-1. The Reds have gone 3-4-0 ATS in Greene's seven starts with a set spread. The Reds have a 2-2 record in Greene's four starts this season when they were the underdog on the moneyline.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (51.3%)

Cubs vs Reds Moneyline

• Looking at the moneyline for Cubs-Reds, Chicago is the favorite at -116, and Cincinnati is -102 playing at home.

Cubs vs Reds Spread

• The Cubs are favored by 1.5 runs on the road versus the Reds. The Cubs are +150 to cover the spread, while the Reds are -182.

Cubs vs Reds Over/Under

• A combined run total of 8.5 has been set for Cubs-Reds on May 23, with the over at -110 and the under at -110.

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Cubs vs Reds Betting Trends

• The Cubs have been victorious in 20, or 71.4%, of the 28 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win 19 times in 27 chances when named as a favorite of at least -116 on the moneyline.
• The Cubs' games have gone over the total in 30 of their 48 opportunities.
• The Cubs have posted a record of 25-23-0 against the spread this season.
• The Reds have compiled a 12-14 record in games they were listed as the moneyline underdog (winning 46.2% of those games).
• Cincinnati has gone 10-12 when it has played as a moneyline underdog with odds of -102 or longer (45.5%).
• The Reds have had an over/under set by oddsmakers 49 times, and have combined with opponents to go over the total in 18 of those games (18-29-2).
• The Reds have a 26-23-0 record ATS this season (covering 53.1% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.387) this season, fueled by 54 hits. He has a .278 batting average and a slugging percentage of .552.
• Among qualifying hitters in the majors, he is 47th in batting average, 15th in on-base percentage, and 12th in slugging.
• Tucker will look for his third straight game with a hit in this matchup. In his last five games he is batting .389 with two home runs, five walks and two RBIs.
• Pete Crow-Armstrong leads Chicago in slugging percentage (.553) and total hits (55) this season. He's batting .279 with an on-base percentage of .313.
• Among all qualifying players, he ranks 44th in batting average, 101st in on-base percentage and 11th in slugging percentage.
• Seiya Suzuki is batting .253 with a .527 slugging percentage and 43 RBI this year.
• Suzuki takes a three-game hitting streak into this matchup. In his last five games he is hitting .316 with two doubles, a home run, three walks and six RBIs.
• Dansby Swanson has 10 home runs, 27 RBI and a batting average of .262 this season.
• Swanson enters this game on a seven-game hitting streak. During his last 10 outings he is hitting .351 with two home runs, four walks and five RBIs.

Reds Player Leaders

• Elly De La Cruz is batting .242 with eight doubles, eight home runs and 20 walks. He's slugging .404 with an on-base percentage of .317.
• Including all qualifying hitters, he is 102nd in batting average, while his on-base percentage is 96th and he is 92nd in slugging.
• TJ Friedl is slugging .391 to lead his team. He has a batting average of .274 with an on-base percentage of .359.
• Including all qualified players, he ranks 58th in batting average, 43rd in on-base percentage and 105th in slugging percentage.
• Gavin Lux has racked up an on-base percentage of .377 and has 45 hits, both team-best figures for the Reds.
• Austin Hays is hitting .316 with six doubles, six home runs and seven walks.

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