Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 6

Odds updated as of 2:11 p.m.

On Sunday in MLB, the Chicago Cubs are up against the San Diego Padres.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Padres Game Info

• Chicago Cubs (7-4) vs. San Diego Padres (7-2)
• Date: Sunday, April 6, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SDPA

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-142) | SD: (+120)
• Spread: CHC: -1.5 (+146) | SD: +1.5 (-176)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 1-1, 5.87 ERA vs Kyle Hart (Padres) - 1-0, 3.60 ERA

This contest's pitching matchup is set, as the Cubs will send Ben Brown (1-1) to the mound, while Kyle Hart (1-0) will answer the bell for the Padres. Brown helped his team cover the spread in his only opportunity this season as a starter. Brown's team won his only start as a favorite this season. Hart has started only one game with a set spread, which the Padres covered. The Padres have always been the moneyline underdog when Hart starts this season.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.1%)

Cubs vs Padres Moneyline

• Chicago is the favorite, -142 on the moneyline, while San Diego is a +120 underdog on the road.

Cubs vs Padres Spread

• The Padres are +1.5 on the spread (-176 to cover), and Chicago is +146 to cover the runline.

Cubs vs Padres Over/Under

• A total of 7.5 runs has been set for the Cubs-Padres game on April 6, with the over available at -100 and the under at -122.

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Cubs vs Padres Betting Trends

• The Cubs have yet to lose any of the four games they have been chosen as the favorite in this season.
• Chicago has been listed as a favorite of -142 or more on two occasions this season and won both games.
• The Cubs and their opponents have gone over the total this season in seven of their 11 opportunities.
• The Cubs have an against the spread record of 7-4-0 in 11 games with a line this season.
• The Padres have won 50% of the games this season they were the underdog on the moneyline (2-2).
• San Diego has played as a moneyline underdog of +120 or longer in just two games this season, which it split 1-1.
• The Padres have combined with opponents to go over the total three times this season for a 3-5-1 record against the over/under.
• The Padres are 6-3-0 against the spread this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.444), slugging percentage (.698) and total hits (13) this season. He has a .302 batting average.
• Among all qualified hitters in MLB, he is 49th in batting average, 17th in on-base percentage, and 11th in slugging.
• Carson Kelly is hitting .467 with a double, a triple, two home runs and six walks, while slugging 1.067 with an on-base percentage of .591.
• Dansby Swanson is batting .233 with a .512 slugging percentage and seven RBI this year.
• Seiya Suzuki has four home runs, 11 RBI and a batting average of .239 this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated an on-base percentage of .462 and a slugging percentage of .529. Both lead the Padres. He's batting .412.
• Including all qualified hitters in MLB, he is fifth in batting average, 12th in on-base percentage and 48th in slugging percentage.
• Tatis hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .368 with two walks and four RBI.
• Jackson Merrill has racked up 12 hits to lead his team. He has a batting average of .375 while slugging .625 with an on-base percentage of .400.
• He is currently 12th in batting average, 30th in on-base percentage and 25th in slugging percentage among all qualified hitters.
• Manny Machado is hitting .333 with three doubles and two walks.
• Gavin Sheets is batting .381 with two doubles, a home run and a walk.

Cubs vs Padres Head to Head

• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/10/2024: 10-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/9/2024: 5-1 CHC (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/8/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/5/2023: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/4/2023: 7-1 CHC (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)

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