Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 5

Odds updated as of 2:12 p.m.

On Saturday in MLB, the Chicago Cubs are playing the San Diego Padres.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Cubs vs Padres Game Info

• Chicago Cubs (6-4) vs. San Diego Padres (7-1)
• Date: Saturday, April 5, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and SDPA

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | SD: (-100)
• Spread: CHC: +1.5 (-210) | SD: -1.5 (+172)
• Total: 6.5 -- Over: (-120) | Under: (-102)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 0-0, 0.00 ERA vs Nick Pivetta (Padres) - 1-0, 0.00 ERA

This contest's pitching matchup is set, as the Cubs will send Matthew Boyd to the mound, while Nick Pivetta (1-0) will get the nod for the Padres. Boyd and his team failed to cover the spread in his only opportunity this season as a starter. This will be Boyd's first start this season with his team as the moneyline favorite. Pivetta has started only one game with a set spread, which the Padres covered. The Padres have always been the moneyline underdog when Pivetta starts this season.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (51.1%)

Cubs vs Padres Moneyline

• The moneyline numbers for Cubs vs. Padres reveal Chicago as the favorite (-118) and San Diego as the underdog (-100) on the road.

Cubs vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Cubs. The Padres are +172 to cover, while the Cubs are -210 to cover as a 1.5-run underdog on the runline.

Cubs vs Padres Over/Under

• Cubs versus Padres, on April 5, has an over/under of 6.5, with the over being -120 and the under -102.

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Cubs vs Padres Betting Trends

• The Cubs have yet to lose any of the three games they have been chosen as the favorite in this season.
• Chicago has been a -118 moneyline favorite on three occasions this season and won every time.
• The Cubs' games have gone over the total in six of their 10 opportunities.
• In 10 games with a line this season, the Cubs have a mark of 6-4-0 against the spread.
• The Padres have won two of the three games they were the underdog on the moneyline this season (66.7%).
• San Diego is 2-1 (winning 66.7% of its games) when playing as a moneyline underdog of -100 or longer.
• The Padres have played in eight games with a set over/under, and have combined with their opponents to go over the total two times (2-5-1).
• The Padres have a 6-2-0 record against the spread this season (covering 75% of the time).

Cubs Player Leaders

• Kyle Tucker has 12 hits and an OBP of .449 to go with a slugging percentage of .744. All three of those stats are tops among Chicago hitters this season. He has a .308 batting average, as well.
• Among qualifying hitters in MLB, his batting average ranks 41st, his on-base percentage ranks 16th, and he is 13th in slugging.
• Seiya Suzuki is batting .256 with two doubles, four home runs and five walks, while slugging .581 with an on-base percentage of .327.
• Among qualified hitters, his batting average ranks him 82nd, his on-base percentage 86th, and his slugging percentage 34th.
• Carson Kelly has collected five base hits, an OBP of .556 and a slugging percentage of .917 this season.
• Dansby Swanson has two home runs, six RBI and a batting average of .205 this season.

Padres Player Leaders

• Fernando Tatis Jr. has a .486 on-base percentage and a .567 slugging percentage, both team-high numbers for the Padres. He's batting .433.
• Including all the qualified hitters in the majors, his batting average ranks third, his on-base percentage is seventh, and he is 37th in slugging.
• Jackson Merrill paces his team with 12 hits. He has a batting average of .429 while slugging .714 with an on-base percentage of .452.
• He ranks fourth in batting average, 15th in on-base percentage and 16th in slugging percentage in the majors.
• Manny Machado is hitting .345 with three doubles and two walks.
• Gavin Sheets is hitting .421 with two doubles, a home run and a walk.

Cubs vs Padres Head to Head

• 4/4/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/8/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/7/2024: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 5/6/2024: 6-3 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/10/2024: 10-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 4/9/2024: 5-1 CHC (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 4/8/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/5/2023: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/4/2023: 7-1 CHC (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/3/2023: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)

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