Cubs vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 29

Odds updated as of 3:11 p.m.

The MLB schedule on Wednesday includes the Chicago Cubs taking on the San Diego Padres.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Padres Game Info

• Chicago Cubs (18-12) vs. San Diego Padres (19-10)
• Date: Wednesday, April 29, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and MARQ

Cubs vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-118) | SD: (+100)
• Spread: CHC: -1.5 (+132) | SD: +1.5 (-160)
• Total: 8.5 -- Over: (-108) | Under: (-112)

Cubs vs Padres Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 1-1, 4.55 ERA vs Matt Waldron (Padres) - 0-1, 12.46 ERA

The probable starters are Jameson Taillon (1-1) for the Cubs and Matt Waldron (0-1) for the Padres. When Taillon starts, his team is 2-3-0 against the spread this season. When Taillon starts a game and his team is the favorite on the moneyline, they have a record of 2-1. Waldron has started two games with set spreads, and the Padres went 1-1-0. The Padres were the moneyline underdog for one Waldron start this season -- they lost.

Cubs vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (53.9%)

Cubs vs Padres Moneyline

• The Cubs vs Padres moneyline has Chicago as a -118 favorite, while San Diego is a +100 underdog at home.

Cubs vs Padres Spread

• The Cubs are 1.5-run road favorites on the runline against the Padres. The Cubs are +132 to cover, and the Padres are -160.

Cubs vs Padres Over/Under

• The Cubs-Padres game on April 29 has been given an over/under of 8.5 runs. The over is set at -108 and the under at -112.

Bet on Chicago Cubs vs. San Diego Padres on FanDuel today!

Cubs vs Padres Betting Trends

• The Cubs have won in 12, or 63.2%, of the 19 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 10-7 in contests when bookmakers favor them by -118 or more on the moneyline.
• The Cubs' games have gone over the total in 19 of their 30 opportunities.
• The Cubs are 15-15-0 against the spread in their 30 games that had a posted line this season.
• The Padres have gone 6-6 in games they were the underdog on the moneyline (winning 50% of those games).
• San Diego has a 5-5 record (winning 50% of its games) when it has played as a moneyline underdog of +100 or longer.
• The Padres have played in 29 games with an over/under set, and have combined with their opponents to go over the total 13 times (13-15-1).
• The Padres have an 18-11-0 record against the spread this season.

Cubs Player Leaders

• Nico Hoerner has an OPS of .824, fueled by an OBP of .369 to go with a slugging percentage of .455. He has a .293 batting average, as well.
• He ranks 28th in batting average, 33rd in on-base percentage, and 59th in slugging among qualifying hitters in the majors.
• Dansby Swanson is batting .214 with two doubles, a triple, six home runs and 20 walks. He's slugging .439 with an on-base percentage of .344.
• He is 140th in batting average, 66th in on-base percentage and 66th in slugging among qualified batters.
• Swanson heads into this game looking to extend his two-game hit streak. In his last five games he is hitting .333 with a double, a triple, a home run, a walk and six RBIs.
• Moises Ballesteros has 24 hits this season and has a slash line of .364/.419/.667.
• Ian Happ leads Chicago with 25 hits, batting .229 this season with 11 extra-base hits.

Padres Player Leaders

• Xander Bogaerts has racked up a team-high OBP (.364) and slugging percentage (.448). He's batting .286.
• Including all qualifying hitters in the big leagues, his batting average places him 35th, his on-base percentage is 39th, and he is 63rd in slugging.
• Bogaerts brings a three-game hitting streak into this game. During his last five outings he is hitting .333 with two home runs, four walks and three RBIs.
• Manny Machado is batting .232 with four doubles, four home runs and 17 walks. He's slugging .400 with an on-base percentage of .342.
• He is currently 117th in batting average, 74th in on-base percentage and 93rd in slugging percentage among all qualifying hitters.
• Ramon Laureano is batting .255 with four doubles, two triples, four home runs and 10 walks.
• Jackson Merrill is hitting .205 with six doubles, three home runs and nine walks.

Cubs vs Padres Head to Head

• 4/28/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/27/2026: 9-7 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/2/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/1/2025: 3-0 SD (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/30/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/16/2025: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/15/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/14/2025: 10-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/6/2025: 8-7 SD (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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