Cubs vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 12:12 a.m.

The Chicago Cubs are among the MLB teams in action on Saturday, up against the Washington Nationals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Nationals Game Info

• Chicago Cubs (81-60) vs. Washington Nationals (56-84)
• Date: Saturday, September 6, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and MASN2

Cubs vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-275) | WSH: (+225)
• Spread: CHC: -1.5 (-128) | WSH: +1.5 (+106)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Cubs vs Nationals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 12-7, 2.94 ERA vs Brad Lord (Nationals) - 4-8, 4.34 ERA

The Cubs will look to Matthew Boyd (12-7) against the Nationals and Brad Lord (4-8). When Boyd starts, his team is 10-16-0 against the spread this season. Boyd's team is 11-9 this season when he starts and they are the moneyline favorite. When Lord starts, the Nationals have gone 7-6-0 against the spread. The Nationals have a 7-4 record in Lord's 11 starts this season when they were the underdog on the moneyline.

Cubs vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (69.8%)

Cubs vs Nationals Moneyline

• The Cubs vs Nationals moneyline has Chicago as a -275 favorite, while Washington is a +225 underdog on the road.

Cubs vs Nationals Spread

• The Nationals are +1.5 on the run line against the Cubs. The Nationals are +106 to cover, and the Cubs are -128.

Cubs vs Nationals Over/Under

• Cubs versus Nationals, on Sept. 6, has an over/under of 9.5, with the over being -100 and the under -122.

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Cubs vs Nationals Betting Trends

• The Cubs have won in 62, or 64.6%, of the 96 contests they have been named as odds-on favorites in this year.
• Chicago has not lost in four games this year when favored by -275 or better on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in 64 of 137 chances this season.
• The Cubs have an against the spread record of 63-74-0 in 137 games with a line this season.
• The Nationals are 48-65 in games they were the underdog on the moneyline (winning 42.5% of those games).
• Washington has played as a moneyline underdog of +225 or longer in only two games this season, which it lost both.
• The Nationals have played in 134 games with a set over/under, and have combined with opponents to go over the total 71 times (71-56-7).
• The Nationals have covered 49.3% of their games this season, going 66-68-0 against the spread.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .381 this season while batting .270 with 86 walks and 89 runs scored. He has a slugging percentage of .472.
• He is 43rd in batting average, seventh in on-base percentage, and 38th in slugging among all qualified batters in baseball.
• Pete Crow-Armstrong has 132 hits, which ranks first among Chicago batters this season. He's batting .253 with 66 extra-base hits. He's also slugging .494 with an on-base percentage of .291.
• Among all qualified hitters, he is 90th in batting average, 141st in on-base percentage and 26th in slugging percentage.
• Crow-Armstrong takes a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .167 with two walks and three RBIs.
• Nico Hoerner has an OPS of .724, fueled by an OBP of .339 and a team-best slugging percentage of .386 this season.
• Seiya Suzuki is batting .244 with a .323 OBP and 89 RBI for Chicago this season.

Nationals Player Leaders

• C.J. Abrams is batting .265 with 29 doubles, five triples, 17 home runs and 34 walks. He's slugging .446 with an on-base percentage of .327.
• Including all the qualified hitters in the big leagues, his batting average puts him 60th, his on-base percentage is 83rd, and he is 67th in slugging.
• James Wood paces his team with 134 hits and a .353 OBP, with a team-leading .470 slugging percentage. He has a batting average of .256.
• Including all qualified hitters, his batting average places him 86th, his on-base percentage ranks 36th, and he is 42nd in slugging.
• Luis Garcia has 26 doubles, a triple, 12 home runs and 23 walks while hitting .260.
• Josh Bell has 13 doubles, a triple, 16 home runs and 54 walks while batting .225.

Cubs vs Nationals Head to Head

• 9/5/2025: 11-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/5/2025: 7-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/4/2025: 2-0 WSH (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/3/2025: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2024: 5-1 WSH (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/20/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/19/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/1/2024: 14-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/31/2024: 5-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/30/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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