Cubs vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 1

Odds updated as of 11:11 p.m.

MLB action on Friday includes the Chicago Cubs playing the Arizona Diamondbacks.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Diamondbacks Game Info

• Chicago Cubs (19-12) vs. Arizona Diamondbacks (16-14)
• Date: Friday, May 1, 2026
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and Dbacks.TV

Cubs vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-134) | ARI: (+116)
• Spread: CHC: -1.5 (+158) | ARI: +1.5 (-192)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Cubs vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 3-1, 4.61 ERA vs Zac Gallen (Diamondbacks) - 1-1, 3.14 ERA

The Cubs will give the nod to Colin Rea (3-1, 4.61 ERA), who is eyeing win No. 4 on the season, and the Diamondbacks will turn to Zac Gallen (1-1, 3.14 ERA). Rea and his team are 2-1-0 ATS this season when he starts. Rea's team won his only start as a favorite this season. When Gallen starts, the Diamondbacks have gone 4-2-0 against the spread. The Diamondbacks have been the moneyline underdog in four of Gallen's starts this season, and they went 2-2 in those matchups.

Cubs vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.9%)

Cubs vs Diamondbacks Moneyline

• Looking at the moneyline for Diamondbacks-Cubs, Arizona is the underdog at +116, and Chicago is -134 playing at home.

Cubs vs Diamondbacks Spread

• The Cubs are hosting the Diamondbacks and are favored by 1.5 runs on the spread. The Cubs are +158 to cover the runline, with the Diamondbacks being -192.

Cubs vs Diamondbacks Over/Under

• An over/under of 7.5 has been set for Cubs-Diamondbacks on May 1, with the over being +102 and the under -124.

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Cubs vs Diamondbacks Betting Trends

• The Cubs have been chosen as favorites in 19 games this year and have walked away with the win 12 times (63.2%) in those games.
• This year Chicago has won seven of 12 games when listed as at least -134 on the moneyline.
• The Cubs' games have gone over the total in 20 of their 31 opportunities.
• The Cubs have an against the spread record of 15-16-0 in 31 games with a line this season.
• The Diamondbacks have gone 9-11 in games they were listed as the moneyline underdog (winning 45% of those games).
• Arizona has a 6-4 record (winning 60% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Diamondbacks have combined with opponents to go over the total 18 times this season for an 18-11-1 record against the over/under.
• The Diamondbacks have collected a 20-10-0 record ATS this season.

Cubs Player Leaders

• Nico Hoerner leads Chicago OPS (.819) this season. He has a .291 batting average, an on-base percentage of .370, and a slugging percentage of .449.
• Among all qualified hitters in baseball, he is 31st in batting average, 36th in on-base percentage, and 58th in slugging.
• Hoerner hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .250 with a double, two walks and three RBIs.
• Dansby Swanson has two doubles, a triple, six home runs and 20 walks. He's batting .214 and slugging .439 with an on-base percentage of .344.
• Among qualified hitters, his batting average ranks him 142nd, his on-base percentage 69th, and his slugging percentage 67th.
• Swanson brings a two-game streak with at least one hit into this one. In his last five games he is batting .333 with a double, a triple, a home run, a walk and six RBIs.
• Ian Happ leads Chicago in total hits (26) this season, and 12 of those have gone for extra bases.
• Moises Ballesteros has five home runs, 16 RBI and a batting average of .338 this season.

Diamondbacks Player Leaders

• Ildemaro Vargas has racked up a team-high OBP (.398) and slugging percentage (.689), while leading the Diamondbacks in hits (34, while batting .378).
• Including all the qualified hitters in the majors, he is first in batting average, 15th in on-base percentage and third in slugging percentage.
• Vargas hopes to build on a 23-game hitting streak in this matchup. In his last 10 outings he is hitting .375 with a double, a triple, four home runs, a walk and 12 RBIs.
• Corbin Carroll is hitting .296 with seven doubles, four triples, four home runs and 16 walks. He's slugging .571 with an on-base percentage of .397.
• Including all qualified hitters, he is 27th in batting average, 17th in on-base percentage and 10th in slugging percentage.
• Nolan Arenado is batting .276 with two doubles, five home runs and six walks.
• Ketel Marte has three doubles, five home runs and 10 walks while hitting .233.

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