Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 3:11 p.m.

The MLB's Sunday schedule includes the Chicago Cubs facing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Cardinals Game Info

• Chicago Cubs (91-70) vs. St. Louis Cardinals (78-83)
• Date: Sunday, September 28, 2025
• Time: 3:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and FDSMW

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-148) | STL: (+126)
• Spread: CHC: -1.5 (+142) | STL: +1.5 (-172)
• Total: 7 -- Over: (-122) | Under: (-100)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Javier Assad (Cubs) - 3-1, 4.26 ERA vs Kyle Leahy (Cardinals) - 4-2, 3.18 ERA

This contest's pitching matchup is set, as the Cubs will send Javier Assad (3-1) to the mound, while Kyle Leahy (4-2) will answer the bell for the Cardinals. Assad and his team are 1-5-0 ATS this season when he starts. Assad has started four games with his team as the moneyline favorite and won each of them. Leahy never pitched as a moneyline underdog a season ago.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (55%)

Cubs vs Cardinals Moneyline

• Chicago is a -148 favorite on the moneyline, while St. Louis is a +126 underdog on the road.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-172 to cover), and Chicago is +142 to cover the runline.

Cubs vs Cardinals Over/Under

• Cubs versus Cardinals, on Sept. 28, has an over/under of 7, with the over being -122 and the under -100.

Bet on Chicago Cubs vs. St. Louis Cardinals on FanDuel today!

Cubs vs Cardinals Betting Trends

• The Cubs have won in 69, or 64.5%, of the 107 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 40-18 when favored by -148 or more this year.
• The Cubs and their opponents have gone over in 74 of their 156 games with a total set by sportsbooks this season.
• The Cubs are 74-82-0 against the spread in their 156 games that had a posted line this season.
• The Cardinals are 43-46 in games they were listed as the moneyline underdog (winning 48.3% of those games).
• St. Louis has a record of 12-23 when playing as a moneyline underdog with odds of +126 or longer (34.3%).
• In the 155 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 80 times (80-70-5).
• The Cardinals have gone 78-77-0 ATS this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago with an OBP of .379 this season while batting .268 with 87 walks and 91 runs scored. He has a slugging percentage of .467.
• Among qualifying hitters in baseball, his batting average ranks 42nd, his on-base percentage ranks seventh, and he is 42nd in slugging.
• Nico Hoerner has hit seven homers this season while driving in 61 runs. He's batting .297 this season and slugging .395 with an on-base percentage of .346.
• Among qualified hitters, his batting average places him eighth, his on-base percentage 44th, and his slugging percentage 110th.
• Pete Crow-Armstrong has 145 hits this season and has a slash line of .247/.287/.481.
• Crow-Armstrong brings a three-game hitting streak into this matchup. In his last five games he is hitting .294 with two home runs and five RBIs.
• Michael Busch leads Chicago in total hits (137) this season while batting .263 with 64 extra-base hits.
• Busch heads into this matchup on a two-game hitting streak. During his last five outings he is hitting .471 with three doubles, a triple, four home runs, four walks and eight RBIs.

Cardinals Player Leaders

• Alec Burleson has accumulated 144 hits with a .459 slugging percentage, both team-best numbers for the Cardinals. He's batting .290 and with an on-base percentage of .343.
• Including all the qualifying hitters in the majors, his batting average ranks 15th, his on-base percentage ranks 50th, and he is 49th in slugging.
• Brendan Donovan's .353 OBP paces his team. He has a batting average of .287 while slugging .422.
• Including all qualifying hitters, he ranks 17th in batting average, 30th in on-base percentage and 80th in slugging percentage.
• Ivan Herrera has 13 doubles, 19 home runs and 43 walks while batting .286.
• Lars Nootbaar has 24 doubles, a triple, 13 home runs and 64 walks while batting .234.

Cubs vs Cardinals Head to Head

• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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