Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for July 29

Odds updated as of 2:12 a.m.

The Wednesday slate in MLB includes a matchup between the Chicago Cubs and the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Cubs vs Cardinals Game Info

• Chicago Cubs (61-46) vs. St. Louis Cardinals (53-54)
• Date: Wednesday, July 29, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-116) | STL: (-102)
• Spread: CHC: -1.5 (+146) | STL: +1.5 (-178)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 6-1, 3.81 ERA vs Dustin May (Cardinals) - 5-7, 4.59 ERA

The Cubs will give the nod to Matthew Boyd (6-1) against the Cardinals and Dustin May (5-7). Boyd and his team have a record of 6-4-0 against the spread when he starts. When Boyd starts a game and his team is the favorite on the moneyline, they have a record of 7-1. When May starts, the Cardinals are 11-9-0 against the spread. The Cardinals are 5-9 in May's 14 starts this season that they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (54.8%)

Cubs vs Cardinals Moneyline

• The moneyline numbers for Cubs vs. Cardinals reveal Chicago as the favorite (-116) and St. Louis as the underdog (-102) despite being the home team.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Cubs. The Cardinals are -178 to cover, and the Cubs are +146.

Cubs vs Cardinals Over/Under

• The over/under for the Cubs versus Cardinals contest on July 29 has been set at 8.5, with +100 odds on the over and -122 odds on the under.

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Cubs vs Cardinals Betting Trends

• The Cubs have won in 39, or 57.4%, of the 68 contests they have been named as odds-on favorites in this year.
• Chicago has a record of 35-29 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Cubs and their opponents have gone over the total this season in 56 of their 102 opportunities.
• In 102 games with a line this season, the Cubs have a mark of 47-55-0 against the spread.
• The Cardinals have won 34 of the 72 games they were listed as the moneyline underdog this season (47.2%).
• St. Louis has a 28-31 record (winning 47.5% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Cardinals have played in 104 games with an over/under set, and have combined with their opponents to go over the total 42 times (42-56-6).
• The Cardinals have covered 54.8% of their games this season, going 57-47-0 ATS.

Cubs Player Leaders

• Pete Crow-Armstrong leads Chicago in OBP (.384), slugging percentage (.535) and total hits (114) this season. He has a .285 batting average.
• He is 19th in batting average, ninth in on-base percentage, and 12th in slugging among all qualified hitters in baseball.
• Nico Hoerner is batting .254 with 23 doubles, a triple, five home runs and 37 walks. He's slugging .348 with an on-base percentage of .318.
• Among qualifiers, he is 76th in batting average, 100th in on-base percentage and 138th in slugging percentage.
• Hoerner brings a five-game streak with at least one hit into this matchup. In his last five games he is batting .429 with a home run, a walk and seven RBIs.
• Dansby Swanson is batting .220 with a .411 slugging percentage and 61 RBI this year.
• Swanson takes a four-game hitting streak into this game. In his last five games he is batting .316 with a double, a walk and three RBIs.
• Alex Bregman has been key for Chicago with 101 hits, an OBP of .339 plus a slugging percentage of .374.
• Bregman heads into this game on a two-game hitting streak. During his last five outings he is hitting .318 with three doubles, a home run, two walks and two RBIs.

Cardinals Player Leaders

• Jordan Walker has 114 hits, a team-high for the Cardinals. He's batting .283 and slugging .504 with an on-base percentage of .345.
• Including all qualifying players in the majors, he is 24th in batting average, 56th in on-base percentage and 17th in slugging percentage.
• Alec Burleson's .464 slugging percentage leads his team. He has a batting average of .285 with an on-base percentage of .345.
• Including all qualified hitters, he is 19th in batting average, 56th in on-base percentage and 43rd in slugging percentage.
• JJ Wetherholt has 10 doubles, 15 home runs and 46 walks while hitting .254.
• Ivan Herrera has a .362 OBP to lead his team.

Cubs vs Cardinals Head to Head

• 7/28/2026: 10-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/5/2026: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/3/2026: 17-1 STL (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/31/2026: 5-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/30/2026: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2026: 6-5 STL (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/28/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/27/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)

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