Top 25 College Basketball Picks & Predictions Today - December 21

A matchup between No. 2 Auburn and No. 16 Purdue at 4:30 PM ET is one of the highlights of Saturday's slate, which features 15 games involving teams ranked in the AP Poll's Top 25. For picks and predictions for each matchup, keep reading.

Prior to today's college basketball action, here's an in-depth dive into the betting odds.

Florida vs. North Florida

• Matchup: North Florida Ospreys at No. 7 Florida Gators
• Projected Winner: Florida (95.00% win probability)
• Spread: Florida (-23.5)
• Time: 12:00 PM ET
• Date: December 21
• TV Channel: SEC Network

Bet on Florida vs. North Florida with FanDuel Sportsbook.

Xavier vs. Marquette

• Matchup: No. 9 Marquette Golden Eagles at Xavier Musketeers
• Projected Winner: Marquette (55.97% win probability)
• Spread: Marquette (-5.5)
• Time: 12:00 PM ET
• Date: December 21
• TV Channel: FOX

Bet on Xavier vs. Marquette with FanDuel Sportsbook.

Butler vs. UConn

• Matchup: No. 11 UConn Huskies at Butler Bulldogs
• Projected Winner: UConn (74.93% win probability)
• Spread: UConn (-9.5)
• Time: 12:00 PM ET
• Date: December 21
• TV Channel: Peacock

Bet on Butler vs. UConn with FanDuel Sportsbook.

Georgia Tech vs. Duke

• Matchup: No. 5 Duke Blue Devils at Georgia Tech Yellow Jackets
• Projected Winner: Duke (86.00% win probability)
• Spread: Duke (-15.5)
• Time: 12:00 PM ET
• Date: December 21
• TV Channel: ACC Network

Bet on Georgia Tech vs. Duke with FanDuel Sportsbook.

Memphis vs. Mississippi State

• Matchup: Mississippi State Bulldogs at No. 21 Memphis Tigers
• Projected Winner: Memphis (54.26% win probability)
• Spread: Memphis (-1.5)
• Time: 12:30 PM ET
• Date: December 21
• TV Channel: CBS

Bet on Memphis vs. Mississippi State with FanDuel Sportsbook.

Michigan State vs. Florida Atlantic

• Matchup: Florida Atlantic Owls at No. 20 Michigan State Spartans
• Projected Winner: Michigan State (65.81% win probability)
• Spread: Michigan State (-13.5)
• Time: 2:00 PM ET
• Date: December 21
• TV Channel: Fox Sports 1

Bet on Michigan State vs. Florida Atlantic with FanDuel Sportsbook.

Houston vs. Texas A&M-CC

• Matchup: Texas A&M-CC Islanders at No. 15 Houston Cougars
• Projected Winner: Houston (93.23% win probability)
• Spread: Houston (-28.5)
• Time: 2:00 PM ET
• Date: December 21
• TV Channel: CBS Sports Network

Bet on Houston vs. Texas A&M-CC with FanDuel Sportsbook.

Clemson vs. Wake Forest

• Matchup: Wake Forest Demon Deacons at No. 25 Clemson Tigers
• Projected Winner: Clemson (68.25% win probability)
• Spread: Clemson (-9.5)
• Time: 2:00 PM ET
• Date: December 21
• TV Channel: ESPN

Bet on Clemson vs. Wake Forest with FanDuel Sportsbook.

North Carolina vs. UCLA

• Matchup: No. 18 UCLA Bruins vs. North Carolina Tar Heels
• Projected Winner: North Carolina (70.06% win probability)
• Spread: UCLA (-1.5)
• Time: 3:00 PM ET
• Date: December 21
• TV Channel: CBS

Bet on North Carolina vs. UCLA with FanDuel Sportsbook.

Auburn vs. Purdue

• Matchup: No. 16 Purdue Boilermakers vs. No. 2 Auburn Tigers
• Projected Winner: Auburn (65.32% win probability)
• Spread: Auburn (-9.5)
• Time: 4:30 PM ET
• Date: December 21
• TV Channel: ESPN

Bet on Auburn vs. Purdue with FanDuel Sportsbook.

Ole Miss vs. Queens

• Matchup: Queens Royals at No. 17 Ole Miss Rebels
• Projected Winner: Ole Miss (92.89% win probability)
• Spread: Ole Miss (-26.5)
• Time: 5:00 PM ET
• Date: December 21
• TV Channel: SEC Network+

Bet on Ole Miss vs. Queens with FanDuel Sportsbook.

Kentucky vs. Ohio State

• Matchup: Ohio State Buckeyes vs. No. 4 Kentucky Wildcats
• Projected Winner: Kentucky (64.39% win probability)
• Spread: Kentucky (-8.5)
• Time: 5:30 PM ET
• Date: December 21
• TV Channel: CBS

Bet on Kentucky vs. Ohio State with FanDuel Sportsbook.

Stanford vs. Oregon

• Matchup: No. 10 Oregon Ducks vs. Stanford Cardinal
• Projected Winner: Oregon (69.33% win probability)
• Spread: Oregon (-5.5)
• Time: 8:00 PM ET
• Date: December 22
• TV Channel: BTN

Bet on Stanford vs. Oregon with FanDuel Sportsbook.

Gonzaga vs. Bucknell

• Matchup: Bucknell Bison at No. 13 Gonzaga Bulldogs
• Projected Winner: Gonzaga (98.62% win probability)
• Spread: Gonzaga (-32.5)
• Time: 9:00 PM ET
• Date: December 22
• TV Channel: ESPN+

Bet on Gonzaga vs. Bucknell with FanDuel Sportsbook.

San Diego State vs. Cal

• Matchup: California Golden Bears vs. No. 23 San Diego State Aztecs
• Projected Winner: San Diego State (81.87% win probability)
• Spread: San Diego State (-5.5)
• Time: 10:30 PM ET
• Date: December 22
• TV Channel: ACC Network

Bet on San Diego State vs. Cal with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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