Clemson vs Notre Dame Basketball Prediction, Odds, Picks, Best Bets for February 26

The Clemson Tigers (22-5, 14-2 ACC) will look to build on a four-game winning streak when they host the Notre Dame Fighting Irish (12-15, 6-10 ACC) on February 26, 2025 at Littlejohn Coliseum.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Clemson vs. Notre Dame Game Info and Odds

• Game day: Wednesday, February 26, 2025
• Game time: 7:00 PM ET
• TV channel: ACC Network
• Location: Clemson, South Carolina
• Arena: Littlejohn Coliseum

Before you wager on Wednesday's Clemson-Notre Dame spread (Clemson -14.5) or over/under (135.5 points), see the betting insights and trends below.

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Clemson vs. Notre Dame: ATS Betting Stats and Trends

• Clemson has won 17 games against the spread this season, while failing to cover 10 times.
• Notre Dame has compiled a 13-14-0 ATS record so far this year.
• Clemson covers the spread when it is a 14.5-point favorite or more 28.6% of the time. That's less often than Notre Dame covers as an underdog of 14.5 or more (100%).
• The Tigers sport a worse record against the spread at home (8-7-0) than they do in away games (7-3-0).
• In 2024-25 against the spread, the Fighting Irish have a better winning percentage at home (.429, 6-8-0 record) than away (.400, 4-6-0).
• Against the spread, in conference play, Clemson is 12-4-0 this season.
• Notre Dame has seven wins against the spread in 16 ACC games this year.

Clemson vs. Notre Dame: Moneyline Betting Stats

• Clemson has been chosen as the moneyline favorite in 20 games this year and has walked away with the win 17 times (85%) in those games.
• The Tigers have been a -1587 moneyline favorite on six occasions this season and won every game.
• Notre Dame has won 9.1% of the games this season it was the underdog on the moneyline (1-10).
• The Fighting Irish have played as a moneyline underdog of +860 or longer in only two games this season, which they lost both.
• The moneyline set for this matchup implies Clemson has a 94.1% chance of coming away with a victory in the contest.

Clemson vs. Notre Dame Head-to-Head Comparison

• Clemson's +297 scoring differential (outscoring opponents by 11 points per game) is a result of scoring 77.5 points per game (86th in college basketball) while giving up 66.5 per contest (42nd in college basketball).
• Chase Hunter leads Clemson, recording 17 points per game (111th in the country).
• Notre Dame has a +38 scoring differential, topping opponents by 1.4 points per game. It is putting up 73.3 points per game, 207th in college basketball, and is allowing 71.9 per contest to rank 182nd in college basketball.
• Markus Burton is 10th in the nation with a team-high 20.3 points per game.
• The 32.4 rebounds per game the Tigers average rank 166th in the country, and are 2.7 more than the 29.7 their opponents grab per outing.
• Ian Schieffelin's 9.4 rebounds per game lead the Tigers and rank 20th in college basketball play.
• The Fighting Irish grab 31.2 rebounds per game (233rd in college basketball) while allowing 28.6 per contest to opponents. They outrebound opponents by 2.6 boards per game.
• Kebba Njie averages 6.2 rebounds per game (274th in college basketball) to lead the Fighting Irish.
• Clemson averages 102.2 points per 100 possessions on offense (42nd in college basketball), and gives up 87.7 points per 100 possessions (53rd in college basketball).
• The Fighting Irish rank 95th in college basketball averaging 99.1 points per 100 possessions on offense, and defensively are 291st, allowing 97.2 points per 100 possessions.

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