Central Michigan vs Buffalo Prediction, Odds, Picks, Best Bets for Week 12 2025

The Central Michigan Chippewas versus the Buffalo Bulls is on the college football schedule for Wednesday.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Central Michigan vs Buffalo Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Central Michigan: (-106) | Buffalo: (-110)
• Spread: Central Michigan: -1.5 (-102) | Buffalo: +1.5 (-120)
• Total: 42.5 -- Over: (-110) | Under: (-110)

Central Michigan vs Buffalo Betting Trends

• Central Michigan is 6-3-0 against the spread this season.
• As 1.5-point favorites or more, Central Michigan is 3-1 against the spread.
• This season, six of Central Michigan's nine games have hit the over.
• Buffalo has four wins in nine contests against the spread this season.
• Buffalo has an ATS record of 3-0 as 1.5-point underdogs or greater.
• Buffalo has seen four of its nine games go over the point total.

Central Michigan vs Buffalo Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Chippewas win (73.2%)

Central Michigan vs Buffalo Point Spread

Buffalo is the underdog by 1.5 points against Central Michigan. Buffalo is -102 to cover the spread, and Central Michigan is -120.

Central Michigan vs Buffalo Over/Under

A combined point total of 42.5 has been set for Central Michigan-Buffalo on Nov. 12, with the over at -110 and the under at -110.

Central Michigan vs Buffalo Moneyline

The Central Michigan vs Buffalo moneyline has Buffalo as a -110 favorite, while Central Michigan is a -106 underdog.

Central Michigan vs. Buffalo Points Insights

Central Michigan vs. Buffalo Game Info

• Game day: Wednesday, November 12, 2025
• Game time: 7 p.m. ET
• TV channel: CBS Sports Network
• Location: Mount Pleasant, Michigan
• Stadium: Kelly/Shorts Stadium

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Check out even more in-depth Central Michigan vs. Buffalo analysis on FanDuel Research.