Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 18

Odds updated as of 7:13 a.m.

The MLB schedule on Wednesday includes the St. Louis Cardinals taking on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (38-35) vs. Chicago White Sox (23-50)
• Date: Wednesday, June 18, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and FDSMW

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-194) | CHW: (+162)
• Spread: STL: -1.5 (-111) | CHW: +1.5 (-108)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 7-2, 3.84 ERA vs Sean Burke (White Sox) - 3-7, 4.71 ERA

This contest's pitching matchup is set, as the Cardinals will send Sonny Gray (7-2) to the mound, while Sean Burke (3-7) will take the ball for the White Sox. Gray and his team have a record of 9-5-0 against the spread when he starts. Gray's team has won 87.5% of his starts when they are favored on the moneyline (7-1). The White Sox have gone 8-4-0 ATS in Burke's 12 starts with a set spread. The White Sox are 6-6 in Burke's 12 starts this season that they were the underdog on the moneyline.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (61.5%)

Cardinals vs White Sox Moneyline

• Chicago is the underdog, +162 on the moneyline, while St. Louis is a -194 favorite despite being on the road.

Cardinals vs White Sox Spread

• The Cardinals are at the White Sox and are favored by 1.5 runs on the spread. The Cardinals are -111 to cover the runline, with the White Sox being -108.

Cardinals vs White Sox Over/Under

• The over/under for Cardinals-White Sox on June 18 is 8.5. The over is -105, and the under is -115.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have come away with 15 wins in the 31 contests they have been listed as the favorites in this season.
• These are the best odds of a victory sportsbooks have given St. Louis this season, with a -194 moneyline set for this game.
• The Cardinals' games have gone over the total in 39 of their 73 opportunities.
• The Cardinals have an against the spread mark of 40-33-0 in 73 games with a line this season.
• The White Sox have been the underdog on the moneyline 69 total times this season. They've gone 21-48 in those games.
• Chicago is 7-26 (winning just 21.2% of its games) when it has played as a moneyline underdog of +162 or longer.
• The White Sox have had an over/under set by oddsmakers 70 times, and have combined with opponents to go over the total in 33 of those games (33-34-3).
• The White Sox have covered 55.7% of their games this season, going 39-31-0 ATS.

Cardinals Player Leaders

• Brendan Donovan has 83 hits and an OBP of .388 to go with a slugging percentage of .451. All three of those stats are best among St. Louis hitters this season. He has a .323 batting average, as well.
• Among all qualified batters in baseball, he is fifth in batting average, 13th in on-base percentage, and 55th in slugging.
• Donovan hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .409 with two doubles and an RBI.
• Nolan Arenado is hitting .244 with 11 doubles, a triple, eight home runs and 22 walks, while slugging .388 with an on-base percentage of .306.
• Among qualifying hitters, his batting average ranks him 102nd, his on-base percentage 117th, and his slugging percentage 115th.
• Arenado takes a seven-game streak with at least one hit into this matchup. In his last 10 outings he is hitting .286 with a double, a home run, two walks and five RBIs.
• Willson Contreras is batting .248 with a .411 slugging percentage and 45 RBI this year.
• Lars Nootbaar has been key for St. Louis with 60 hits, an OBP of .330 plus a slugging percentage of .357.

White Sox Player Leaders

• Miguel Vargas has accumulated a team-high OBP (.321) and slugging percentage (.441), and paces the White Sox in hits (62, while batting .242).
• Including all the qualifying players in the majors, his batting average is 107th, his on-base percentage ranks 94th, and he is 64th in slugging.
• Vargas takes a six-game hitting streak into this matchup. In his last 10 games he is hitting .270 with four doubles, a triple, two home runs, five walks and five RBIs.
• Chase Meidroth is hitting .276 with five doubles, two home runs and 23 walks. He's slugging .337 with an on-base percentage of .358.
• Andrew Benintendi is batting .235 with nine doubles, a triple, six home runs and 15 walks.
• Luis Robert is batting .190 with eight doubles, six home runs and 26 walks.

Cardinals vs White Sox Head to Head

• 6/17/2025: 12-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/5/2024: 5-1 CHW (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/4/2024: 6-5 CHW (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/3/2024: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 7/9/2023: 4-3 STL (Favorite: White Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/8/2023: 3-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 10, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2023: 8-7 CHW (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!