Cardinals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 17

Odds updated as of 7:13 a.m.

MLB action on Tuesday includes the St. Louis Cardinals playing the Chicago White Sox.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs White Sox Game Info

• St. Louis Cardinals (37-35) vs. Chicago White Sox (23-49)
• Date: Tuesday, June 17, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and FDSMW

Cardinals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-154) | CHW: (+130)
• Spread: STL: -1.5 (+108) | CHW: +1.5 (-130)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs White Sox Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 3-6, 4.17 ERA vs Shane Smith (White Sox) - 3-3, 2.37 ERA

The probable starters are Matthew Liberatore (3-6) for the Cardinals and Shane Smith (3-3) for the White Sox. When Liberatore starts, his team is 4-9-0 against the spread this season. When Liberatore starts a game and his team is the favorite on the moneyline, they have a record of 2-7. The White Sox have gone 7-6-0 against the spread when Smith starts. The White Sox have a 4-8 record in Smith's 12 starts this season when they were the moneyline underdog.

Cardinals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.3%)

Cardinals vs White Sox Moneyline

• Chicago is a +130 underdog on the moneyline, while St. Louis is a -154 favorite on the road.

Cardinals vs White Sox Spread

• The Cardinals are 1.5-run road favorites on the runline against the White Sox. The Cardinals are +108 to cover, and the White Sox are -130.

Cardinals vs White Sox Over/Under

• A total of 8.5 runs has been set for the Cardinals-White Sox contest on June 17, with the over available at -105 and the under at -115.

Bet on St. Louis Cardinals vs. Chicago White Sox on FanDuel today!

Cardinals vs White Sox Betting Trends

• The Cardinals have been chosen as favorites in 30 games this year and have walked away with the win 14 times (46.7%) in those games.
• St. Louis has a record of 2-2 in contests when bookmakers favor them by -154 or more on the moneyline.
• The Cardinals and their opponents have gone over in 38 of their 72 games with a total set by sportsbooks this season.
• The Cardinals have an against the spread mark of 39-33-0 in 72 games with a line this season.
• The White Sox have compiled a 21-47 record in games they were listed as the moneyline underdog (winning 30.9% of those games).
• Chicago is 17-41 (winning just 29.3% of its games) when it has played as a moneyline underdog of +130 or longer.
• The White Sox have had an over/under set by bookmakers 69 times, and have combined with opponents to go over the total in 32 of those games (32-34-3).
• The White Sox have covered 56.5% of their games this season, going 39-30-0 against the spread.

Cardinals Player Leaders

• Brendan Donovan has 79 hits and an OBP of .381 to go with a slugging percentage of .440. All three of those stats are best among St. Louis hitters this season. He has a .313 batting average, as well.
• Among qualifying batters in baseball, his batting average ranks 10th, his on-base percentage ranks 15th, and he is 65th in slugging.
• Nolan Arenado has 11 doubles, a triple, eight home runs and 21 walks. He's batting .243 and slugging .388 with an on-base percentage of .304.
• Among qualifying batters, he is 107th in batting average, 122nd in on-base percentage and 115th in slugging percentage.
• Arenado has picked up at least one hit in six games in a row. During his last 10 outings he is hitting .333 with a double, a home run, a walk and five RBIs.
• Willson Contreras has 64 hits this season and has a slash line of .251/.336/.416.
• Lars Nootbaar is batting .226 with a .329 OBP and 28 RBI for St. Louis this season.

White Sox Player Leaders

• Miguel Vargas has totaled 61 hits with a .322 on-base percentage and a .440 slugging percentage, all club-bests for the White Sox. He's batting .242.
• He ranks 112th in batting average, 92nd in on-base percentage and 65th in slugging percentage among all qualifying hitters in the majors.
• Vargas heads into this game on a five-game hitting streak. In his last five games he is hitting .350 with three doubles, a triple, a home run, two walks and two RBIs.
• Chase Meidroth has five doubles, two home runs and 23 walks while hitting .282. He's slugging .345 with an on-base percentage of .365.
• Andrew Benintendi has nine doubles, a triple, six home runs and 15 walks while batting .235.
• Luis Robert is hitting .194 with eight doubles, six home runs and 26 walks.

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