Cardinals vs Rockies Prediction, Odds, Moneyline, Spread & Over/Under for July 21

Odds updated as of 10:12 a.m.

Monday's slate in the MLB includes a matchup between the St. Louis Cardinals and the Colorado Rockies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Cardinals vs Rockies Game Info

• St. Louis Cardinals (51-49) vs. Colorado Rockies (24-75)
• Date: Monday, July 21, 2025
• Time: 8:40 p.m. ET
• Venue: Coors Field -- Denver, Colorado
• Coverage: COLR and FDSMW

Cardinals vs Rockies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-154) | COL: (+130)
• Spread: STL: -1.5 (-106) | COL: +1.5 (-113)
• Total: 11.5 -- Over: (-110) | Under: (-110)

Cardinals vs Rockies Probable Starting Pitchers

Probable Pitchers: Michael McGreevy (Cardinals) - 0-0, 0.00 ERA vs Austin Gomber (Rockies) - 0-3, 5.65 ERA

The Cardinals will look to Michael McGreevy against the Rockies and Austin Gomber (0-3). McGreevy did not appear in a game when his team was the moneyline favorite last season. The Rockies have a 1-5-0 ATS record in Gomber's six starts that had a set spread. The Rockies have been the moneyline underdog in six of Gomber's starts this season, and they went 1-5 in those games.

Cardinals vs Rockies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (62.8%)

Cardinals vs Rockies Moneyline

• Looking at the moneyline for Cardinals-Rockies, St. Louis is the favorite at -154, and Colorado is +130 playing at home.

Cardinals vs Rockies Spread

• The Rockies are +1.5 on the spread (-113 to cover), and St. Louis is -106 to cover the runline.

Cardinals vs Rockies Over/Under

• Cardinals versus Rockies, on July 21, has an over/under of 11.5, with the over being -110 and the under -110.

Bet on St. Louis Cardinals vs. Colorado Rockies on FanDuel today!

Cardinals vs Rockies Betting Trends

• The Cardinals have come away with 23 wins in the 43 contests they have been listed as the favorites in this season.
• This season St. Louis has been victorious five times in seven chances when named as a favorite of at least -154 on the moneyline.
• Contests with the Cardinals have gone over the total set by bookmakers in 52 of 97 chances this season.
• The Cardinals are 52-45-0 against the spread in their 97 games with a line set by sportsbooks this season.
• The Rockies are 22-71 in games they were listed as the moneyline underdog (winning 23.7% of those games).
• When playing as a moneyline underdog with odds of +130 or longer, Colorado has an 18-65 record (winning only 21.7% of its games).
• In the 97 games bookmakers have set an over/under for the Rockies, they have combined with opponents to go over the total 39 times (39-55-3).
• The Rockies have a 39-58-0 record against the spread this season (covering 40.2% of the time).

Cardinals Player Leaders

• Brendan Donovan has an OPS of .784, fueled by an OBP of .363 to go with a slugging percentage of .421. He has a .291 batting average, as well.
• Among all qualifying batters in MLB, he ranks 16th in batting average, 31st in on-base percentage, and 83rd in slugging.
• Alec Burleson leads St. Louis with 88 hits. He is batting .293 this season and has 29 extra-base hits. He's also slugging .470 with an on-base percentage of .340.
• His batting average is 13th among qualified players, his on-base percentage 60th, and his slugging percentage 42nd.
• Burleson brings a four-game streak with at least one hit into this one. During his last five outings he is batting .313 with a home run, three walks and an RBI.
• Nolan Arenado is batting .241 with a .381 slugging percentage and 42 RBI this year.
• Masyn Winn has been key for St. Louis with 89 hits, an OBP of .322 plus a slugging percentage of .383.
• Winn has safely hit in four straight games. In his last five games he is batting .350 with a walk.

Rockies Player Leaders

• Hunter Goodman has totaled 92 hits with a .521 slugging percentage, both team-high figures for the Rockies. He's batting .279 and with an on-base percentage of .325.
• Including all qualifying hitters in MLB, his batting average places him 39th, his on-base percentage is 84th, and he is 14th in slugging.
• Jordan Beck has a .328 on-base percentage to pace his team. He has a batting average of .275 while slugging .463.
• Including all qualified hitters, he is 47th in batting average, 77th in on-base percentage and 49th in slugging percentage.
• Mickey Moniak has 11 doubles, six triples, 14 home runs and 16 walks while batting .267.
• Ryan McMahon has 15 doubles, a triple, 15 home runs and 46 walks while hitting .217.

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