Cardinals vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for July 26

Odds updated as of 10:13 a.m.

In MLB action on Saturday, the St. Louis Cardinals play the San Diego Padres.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Padres Game Info

• St. Louis Cardinals (54-51) vs. San Diego Padres (55-49)
• Date: Saturday, July 26, 2025
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and SDPA

Cardinals vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-146) | SD: (+124)
• Spread: STL: -1.5 (+132) | SD: +1.5 (-160)
• Total: 9 -- Over: (-110) | Under: (-110)

Cardinals vs Padres Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 6-7, 4.13 ERA vs Randy Vasquez (Padres) - 3-4, 3.73 ERA

The Cardinals will give the nod to Matthew Liberatore (6-7, 4.13 ERA), who is eyeing win No. 7 on the season, and the Padres will counter with Randy Vasquez (3-4, 3.73 ERA). Liberatore's team is 9-9-0 against the spread in his starts this season. Liberatore's team has a record of 4-8 this season when he starts and they are the favorite on the moneyline. When Vasquez starts, the Padres have gone 12-7-0 against the spread. The Padres have been the underdog on the moneyline in 14 of Vasquez's starts this season, and they went 7-7 in those games.

Cardinals vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (55.6%)

Cardinals vs Padres Moneyline

• The moneyline numbers for Cardinals vs. Padres reveal St. Louis as the favorite (-146) and San Diego as the underdog (+124) on the road.

Cardinals vs Padres Spread

• The Padres are +1.5 on the run line against the Cardinals. The Padres are -160 to cover, and the Cardinals are +132.

Cardinals vs Padres Over/Under

• The over/under for Cardinals-Padres on July 26 is 9. The over is -110, and the under is -110.

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Cardinals vs Padres Betting Trends

• The Cardinals have come away with 25 wins in the 47 contests they have been listed as the favorites in this season.
• This season St. Louis has been victorious nine times in 13 chances when named as a favorite of at least -146 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 53 of their 102 opportunities.
• The Cardinals are 55-47-0 against the spread in their 102 games with a line set by sportsbooks this season.
• The Padres have been the underdog on the moneyline 48 total times this season. They've finished 22-26 in those games.
• San Diego has gone 12-14 when it has played as a moneyline underdog with odds of +124 or longer (46.2%).
• The Padres have played in 102 games with an over/under set, and have combined with their opponents to go over the total 42 times (42-57-3).
• The Padres have a 55-47-0 record ATS this season (covering 53.9% of the time).

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with an OBP of .360, plus a team-best slugging percentage of .428. He's batting .293 on the season.
• Among the qualified hitters in MLB, his batting average ranks 13th, his on-base percentage ranks 32nd, and he is 78th in slugging.
• Willson Contreras has 97 hits, which ranks first among St. Louis batters this season. He's batting .266 with 42 extra-base hits. He's also slugging .458 with an on-base percentage of .351.
• Among all qualifying players, he is 73rd in batting average, 45th in on-base percentage and 54th in slugging percentage.
• Contreras brings a six-game streak with at least one hit into this contest. During his last 10 games he is batting .351 with seven doubles, two home runs, three walks and eight RBIs.
• Nolan Arenado has collected 83 base hits, an OBP of .298 and a slugging percentage of .375 this season.
• Alec Burleson has 12 home runs, 44 RBI and a batting average of .285 this season.

Padres Player Leaders

• Manny Machado has racked up a slugging percentage of .494 and has 116 hits, both team-high numbers for the Padres. He's batting .291 and with an on-base percentage of .350.
• Including all the qualified hitters in MLB, he is 15th in batting average, 49th in on-base percentage and 25th in slugging percentage.
• Machado enters this matchup on a three-game hitting streak. In his last five games he is hitting .333 with a double, a home run and three RBIs.
• Fernando Tatis Jr. leads his team with a .365 OBP. He has a batting average of .269 while slugging .452.
• Including all qualifying hitters, he ranks 57th in batting average, 26th in on-base percentage and 59th in slugging percentage.
• Luis Arraez is hitting .287 with 20 doubles, four triples, five home runs and 20 walks.
• Xander Bogaerts is batting .269 with 23 doubles, six home runs and 43 walks.

Cardinals vs Padres Head to Head

• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/2/2024: 5-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/1/2024: 6-2 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/24/2023: 12-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -200, Underdog Moneyline: +168)

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