Cardinals vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 12:11 a.m.

The Baltimore Orioles will face the St. Louis Cardinals in MLB action on Monday.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Cardinals Game Info

• Baltimore Orioles (18-34) vs. St. Louis Cardinals (30-23)
• Date: Monday, May 26, 2025
• Time: 3:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and FDSMW

Orioles vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-108) | STL: (-108)
• Spread: BAL: +1.5 (-170) | STL: -1.5 (+140)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Orioles vs Cardinals Probable Starting Pitchers

Probable Pitchers: Charlie Morton (Orioles) - 0-7, 7.68 ERA vs Erick Fedde (Cardinals) - 3-3, 3.77 ERA

The probable starters are Charlie Morton (0-7) for the Orioles and Erick Fedde (3-3) for the Cardinals. Morton and his team have yet to cover the spread in any of their six chances this season. Morton and his team have lost each of the four games he's started as the moneyline favorite. The Cardinals have gone 6-4-0 ATS in Fedde's 10 starts that had a set spread. The Cardinals are 2-5 in Fedde's seven starts this season that they were the moneyline underdog.

Orioles vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.4%)

Orioles vs Cardinals Moneyline

• Baltimore is a -108 favorite on the moneyline, while St. Louis is a -108 underdog on the road.

Orioles vs Cardinals Spread

Orioles vs Cardinals Over/Under

• The Orioles-Cardinals game on May 26 has been given an over/under of 9.5 runs. The over is set at -100 and the under at -122.

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Orioles vs Cardinals Betting Trends

• The Orioles have been favorites in 27 games this season and have come away with the win nine times (33.3%) in those contests.
• This season Baltimore has been victorious nine times in 29 chances when named as a favorite of at least -108 on the moneyline.
• The Orioles and their opponents have gone over the total this season in 26 of their 52 opportunities.
• In 52 games with a line this season, the Orioles have a mark of 17-35-0 against the spread.
• The Cardinals have been the underdog on the moneyline 34 total times this season. They've gone 19-15 in those games.
• St. Louis is 19-15 (winning 55.9% of its games) when playing as a moneyline underdog of -108 or longer.
• The Cardinals have played in 53 games with an over/under set, and have combined with their opponents to go over the total 27 times (27-24-2).
• The Cardinals have a 30-23-0 record against the spread this season (covering 56.6% of the time).

Orioles Player Leaders

• Ryan O'Hearn leads Baltimore with 49 hits and an OBP of .419, plus a team-best slugging percentage of .537. He's batting .329.
• Among all qualified hitters in the majors, he ranks fifth in batting average, fifth in on-base percentage, and 15th in slugging.
• O'Hearn has hit safely in five straight games. In his last five games he is hitting .571 with two doubles, a home run, two walks and four RBIs.
• Cedric Mullins has nine doubles, 10 home runs and 23 walks. He's batting .226 and slugging .446 with an on-base percentage of .320.
• Among qualifying batters, he ranks 130th in batting average, 94th in on-base percentage and 60th in slugging percentage.
• Adley Rutschman has collected 37 base hits, an OBP of .310 and a slugging percentage of .349 this season.
• Gunnar Henderson has seven home runs, 14 RBI and a batting average of .265 this season.

Cardinals Player Leaders

• Brendan Donovan has an on-base percentage of .388, a slugging percentage of .460, and has 65 hits, all club-highs for the Cardinals (while batting .328).
• Including all qualified hitters in MLB, he is sixth in batting average, 14th in on-base percentage and 52nd in slugging percentage.
• Lars Nootbaar is batting .244 with 10 doubles, seven home runs and 32 walks. He's slugging .398 with an on-base percentage of .350.
• Including all qualified hitters, he ranks 99th in batting average, 48th in on-base percentage and 101st in slugging percentage.
• Nolan Arenado has 10 doubles, a triple, five home runs and 18 walks while batting .234.
• Willson Contreras has nine doubles, six home runs and 16 walks while hitting .250.

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