Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 29

Odds updated as of 2:11 a.m.

The St. Louis Cardinals versus the Cleveland Guardians is on the MLB schedule for Sunday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (46-38) vs. Cleveland Guardians (40-41)
• Date: Sunday, June 29, 2025
• Time: 12:05 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Roku

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-126) | CLE: (+108)
• Spread: STL: -1.5 (+132) | CLE: +1.5 (-160)
• Total: 8 -- Over: (-128) | Under: (+104)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 5-6, 3.96 ERA vs Logan Allen (Guardians) - 5-5, 4.25 ERA

The Cardinals will give the ball to Matthew Liberatore (5-6, 3.96 ERA), who is eyeing win No. 6 on the season, and the Guardians will counter with Logan Allen (5-5, 4.25 ERA). Liberatore and his team have a record of 6-9-0 against the spread when he starts. When Liberatore starts a game and his team is the favorite on the moneyline, they have a record of 3-7. The Guardians are 5-8-0 against the spread when Allen starts. The Guardians have a 4-6 record in Allen's 10 starts this season when they were the moneyline underdog.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.9%)

Cardinals vs Guardians Moneyline

• St. Louis is the favorite, -126 on the moneyline, while Cleveland is a +108 underdog despite being at home.

Cardinals vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Cardinals. The Guardians are -160 to cover the spread, and the Cardinals are +132.

Cardinals vs Guardians Over/Under

• The over/under for Cardinals-Guardians on June 29 is 8. The over is -128, and the under is +104.

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Cardinals vs Guardians Betting Trends

• The Cardinals have been chosen as favorites in 36 games this year and have walked away with the win 20 times (55.6%) in those games.
• St. Louis has a record of 15-7 when favored by -126 or more this year.
• The Cardinals' games have gone over the total in 44 of their 84 opportunities.
• In 84 games with a line this season, the Cardinals have a mark of 46-38-0 against the spread.
• The Guardians have won 42.9% of the games this season they were the moneyline underdog (21-28).
• Cleveland has a record of 9-20 when it has played as a moneyline underdog with odds of +108 or longer (31%).
• The Guardians have had an over/under set by bookmakers 79 times, and have combined with opponents to go over the total in 34 of those games (34-42-3).
• The Guardians have a 38-41-0 record ATS this season (covering 48.1% of the time).

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with an OBP of .372, plus a team-best slugging percentage of .434. He's batting .302 on the season.
• Among all qualifying hitters in MLB, he is 13th in batting average, 23rd in on-base percentage, and 70th in slugging.
• Donovan will look for his third straight game with a hit in this contest. During his last five outings he is hitting .222 with a home run, three walks and two RBIs.
• Nolan Arenado is hitting .245 with 12 doubles, a triple, 10 home runs and 24 walks. He's slugging .393 with an on-base percentage of .306.
• He is 109th in batting average, 120th in on-base percentage and 112th in slugging in the majors.
• Arenado has picked up at least one hit in two games in a row. During his last five outings he is hitting .158 with a double, a walk and two RBIs.
• Willson Contreras is batting .249 with a .427 slugging percentage and 51 RBI this year.
• Contreras heads into this game with two games in a row with at least one hit. In his last five games he is batting .267 with a double, a home run, four walks and an RBI.
• Lars Nootbaar has been key for St. Louis with 68 hits, an OBP of .334 plus a slugging percentage of .381.

Guardians Player Leaders

• Jose Ramirez has racked up 92 hits with a .373 on-base percentage and a .505 slugging percentage, all club-bests for the Guardians. He's batting .312.
• Including all qualifying hitters, he is eighth in batting average, while his on-base percentage is 22nd and he is 21st in slugging.
• Steven Kwan is batting .300 with 18 doubles, a triple, six home runs and 28 walks. He's slugging .426 with an on-base percentage of .363.
• His batting average is 14th among all qualified players, his on-base percentage ranks 27th, and he is 77th in slugging.
• Carlos Santana has six doubles, nine home runs and 36 walks while hitting .231.
• Kyle Manzardo has 11 doubles, two triples, 13 home runs and 25 walks while hitting .223.

Cardinals vs Guardians Head to Head

• 6/28/2025: 9-6 STL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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