Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 27

Odds updated as of 4:13 a.m.

The St. Louis Cardinals are among the MLB teams busy on Friday, versus the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (44-38) vs. Cleveland Guardians (40-39)
• Date: Friday, June 27, 2025
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Apple TV+

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-130) | CLE: (+110)
• Spread: STL: -1.5 (+126) | CLE: +1.5 (-152)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 7-2, 3.72 ERA vs Luis Ortiz (Guardians) - 4-8, 4.30 ERA

The probable starters are Sonny Gray (7-2) for the Cardinals and Luis Ortiz (4-8) for the Guardians. Gray and his team have a record of 9-6-0 against the spread when he starts. Gray's team has a record of 8-1 this season when he starts and they are the favorite on the moneyline. The Guardians have a 6-9-0 record against the spread in Ortiz's starts. The Guardians are 3-5 in Ortiz's eight starts this season that they were the moneyline underdog.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (57.6%)

Cardinals vs Guardians Moneyline

• Looking at the moneyline for Guardians-Cardinals, Cleveland is the underdog at +110, and St. Louis is -130 playing on the road.

Cardinals vs Guardians Spread

• The Cardinals are at the Guardians and are favored by 1.5 runs (+126 to cover) on the runline. Cleveland is -152 to cover.

Cardinals vs Guardians Over/Under

• A total of 8.5 runs has been set for the Cardinals-Guardians contest on June 27, with the over available at -106 and the under at -114.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have won in 19, or 54.3%, of the 35 contests they have been named as odds-on favorites in this year.
• This year St. Louis has won 13 of 19 games when listed as at least -130 on the moneyline.
• The Cardinals and their opponents have gone over the total this season in 43 of their 82 opportunities.
• The Cardinals have posted a record of 44-38-0 against the spread this season.
• The Guardians have a 21-27 record in games they were the underdog on the moneyline (winning 43.8% of those games).
• Cleveland has a 9-15 record (winning just 37.5% of its games) when playing as a moneyline underdog of +110 or longer.
• The Guardians have played in 77 games with a set over/under, and have combined with their opponents to go over the total 33 times (33-41-3).
• The Guardians have a 38-39-0 record ATS this season (covering 49.4% of the time).

Cardinals Player Leaders

• Nolan Arenado is hitting .242 with 11 doubles, a triple, 10 home runs and 24 walks. He has an on-base percentage of .305 and a slugging percentage of .391.
• Among qualified hitters in baseball, he ranks 116th in batting average, 123rd in on-base percentage, and 115th in slugging.
• Brendan Donovan is slashing .301/.368/.426 this season and leads the Cardinals with an OPS of .793.
• He is 13th in batting average, 24th in on-base percentage and 78th in slugging among qualified hitters.
• Lars Nootbaar has collected 67 base hits, an OBP of .337 and a slugging percentage of .388 this season.
• Nootbaar has picked up a hit in six games in a row. During his last 10 outings he is batting .184 with a double, three home runs, six walks and seven RBIs.
• Masyn Winn is batting .257 with a .323 OBP and 29 RBI for St. Louis this season.
• Winn heads into this game on a three-game hitting streak. During his last five outings he is hitting .278 with a double, a home run, a walk and four RBIs.

Guardians Player Leaders

• Jose Ramirez has 92 hits with a .378 on-base percentage and a .514 slugging percentage, all club-bests for the Guardians. He's batting .317.
• Including all qualified hitters in the big leagues, he is sixth in batting average, 17th in on-base percentage and 16th in slugging percentage.
• Steven Kwan is batting .306 with 18 doubles, six home runs and 28 walks. He's slugging .429 with an on-base percentage of .370.
• His batting average is 11th among all qualified players, his on-base percentage is 23rd, and he is 74th in slugging.
• Carlos Santana is hitting .234 with six doubles, nine home runs and 35 walks.
• Kyle Manzardo is batting .222 with 11 doubles, two triples, 12 home runs and 25 walks.

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