Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 15

Odds updated as of 9:11 p.m.

Wednesday's slate in the MLB includes a matchup between the St. Louis Cardinals and the Cleveland Guardians.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (8-8) vs. Cleveland Guardians (10-7)
• Date: Wednesday, April 15, 2026
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and CleGuardians.TV

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | CLE: (-102)
• Spread: STL: +1.5 (-205) | CLE: -1.5 (+168)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Dustin May (Cardinals) - 1-2, 9.45 ERA vs Slade Cecconi (Guardians) - 0-2, 5.74 ERA

The Cardinals will give the nod to Dustin May (1-2, 9.45 ERA), who is eyeing win No. 2 on the season, and the Guardians will turn to Slade Cecconi (0-2, 5.74 ERA). May's team is 1-2-0 against the spread this season in his starts. This will be May's first start this season with his team as the moneyline favorite. The Guardians have a 1-2-0 ATS record in Cecconi's three starts with a set spread. The Guardians were the moneyline underdog for three Cecconi starts this season -- they lost each time.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (52.6%)

Cardinals vs Guardians Moneyline

• Looking at the moneyline for Cardinals-Guardians, St. Louis is the favorite at -116, and Cleveland is -102 playing on the road.

Cardinals vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Cardinals. The Guardians are +168 to cover, while the Cardinals are -205 to cover as a 1.5-run underdog on the runline.

Cardinals vs Guardians Over/Under

• Cardinals versus Guardians on April 15 has an over/under of 8.5 runs, with the odds on the over -105 and the under set at -115.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have split the two match ups they have played as odds-on favorites this season.
• St. Louis has been listed as a favorite of -116 or more on two occasions this season and split those games.
• The Cardinals' games have gone over the total in nine of their 16 opportunities.
• The Cardinals are 7-9-0 against the spread in their 16 games that had a posted line this season.
• The Guardians have compiled an 8-6 record in games they were listed as the moneyline underdog (winning 57.1% of those games).
• Cleveland has a record of 7-6 when it has played as a moneyline underdog with odds of -102 or longer (53.8%).
• The Guardians have combined with opponents to go over the total eight times this season for an 8-9-0 record against the over/under.
• The Guardians have an 11-6-0 record against the spread this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 20 hits and an OBP of .394, plus a team-best slugging percentage of .767. He's batting .333.
• Among all qualified hitters in the majors, he is 11th in batting average, 31st in on-base percentage, and first in slugging.
• Walker will look for his 10th straight game with a hit in this contest. During his last 10 outings he is batting .366 with seven home runs, three walks and 12 RBIs.
• Alec Burleson is hitting .271 with three doubles, two home runs and 11 walks. He's slugging .424 with an on-base percentage of .380.
• Among all qualified batters, he is 64th in batting average, 40th in on-base percentage and 72nd in slugging percentage.
• Burleson enters this game looking to extend his two-game hit streak. During his last five outings he is hitting .368 with a double, a home run, two walks and five RBIs.
• JJ Wetherholt is batting .213 with a .279 slugging percentage and five RBI this year.
• Ivan Herrera has no home runs, but six RBI and a batting average of .193 this season.
• Herrera brings a two-game hitting streak into this matchup. In his last five games he is hitting .222 with four walks.

Guardians Player Leaders

• Chase DeLauter has racked up 15 hits, a team-best for the Guardians. He's batting .300 and slugging .680 with an on-base percentage of .379.
• Including all qualifying hitters, he is 41st in batting average, while his on-base percentage is 42nd and he is fifth in slugging.
• DeLauter hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .333 with four doubles, four walks and three RBIs.
• Jose Ramirez has four doubles, two home runs and nine walks while batting .200. He's slugging .354 with an on-base percentage of .297.
• He is currently 141st in batting average, 128th in on-base percentage and 110th in slugging percentage among all qualifying batters.
• Angel Martinez has an on-base percentage of .385, a team-high for the Guardians.
• Steven Kwan is slugging .339 to lead his team.

Cardinals vs Guardians Head to Head

• 4/13/2026: 9-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 6/29/2025: 7-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/28/2025: 9-6 STL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 5-0 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/22/2024: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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