Cardinals vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 23

Odds updated as of 7:11 p.m.

Monday's slate in the MLB includes a matchup between the Chicago Cubs and the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Cubs vs Cardinals Game Info

• Chicago Cubs (46-31) vs. St. Louis Cardinals (42-36)
• Date: Monday, June 23, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-120) | STL: (+102)
• Spread: CHC: -1.5 (+128) | STL: +1.5 (-154)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 4-5, 5.57 ERA vs Matthew Liberatore (Cardinals) - 4-6, 4.08 ERA

The Cubs will give the nod to Ben Brown (4-5, 5.57 ERA), who is eyeing win No. 5 on the season, and the Cardinals will turn to Matthew Liberatore (4-6, 4.08 ERA). When Brown starts, his team is 6-7-0 against the spread this season. Brown's team is 6-3 this season when he starts and they are the moneyline favorite. The Cardinals are 5-9-0 against the spread when Liberatore starts. The Cardinals are 3-1 in Liberatore's four starts this season that they were the moneyline underdog.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51%)

Cubs vs Cardinals Moneyline

• Looking at the moneyline for Cubs-Cardinals, Chicago is the favorite at -120, and St. Louis is +102 playing at home.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-154 to cover), and Chicago is +128 to cover the runline.

Cubs vs Cardinals Over/Under

• Cubs versus Cardinals, on June 23, has an over/under of 8.5, with the over being -120 and the under -102.

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Cubs vs Cardinals Betting Trends

• The Cubs have been favorites in 49 games this season and have come away with the win 35 times (71.4%) in those contests.
• Chicago has a record of 32-12 in contests when bookmakers favor them by -120 or more on the moneyline.
• The Cubs and their opponents have gone over in 40 of their 75 games with a total set by sportsbooks this season.
• The Cubs are 38-37-0 against the spread in their 75 games with a line set by sportsbooks this season.
• The Cardinals have a 22-20 record in games they were listed as the moneyline underdog (winning 52.4% of those games).
• St. Louis has a record of 11-15 in games it has played as a moneyline underdog with odds of +102 or longer (42.3%).
• In the 78 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 41 times (41-34-3).
• The Cardinals have a 42-36-0 record against the spread this season (covering 53.8% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago OPS (.923) this season. He has a .285 batting average, an on-base percentage of .395, and a slugging percentage of .528.
• Among qualified batters in the majors, his batting average ranks 31st, his on-base percentage ranks sixth, and he is 14th in slugging.
• Tucker hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .400 with three doubles, two home runs, three walks and three RBIs.
• Pete Crow-Armstrong leads Chicago with 80 hits. He is batting .269 this season and has 41 extra-base hits. He's also slugging .559 with an on-base percentage of .307.
• Among all qualified batters, he is 56th in batting average, 122nd in on-base percentage and seventh in slugging percentage.
• Crow-Armstrong brings a two-game streak with at least one hit into this one. During his last five outings he is batting .294 with a double, three home runs, a walk and four RBIs.
• Seiya Suzuki has 75 hits this season and has a slash line of .256/.312/.539.
• Nico Hoerner has been key for Chicago with 80 hits, an OBP of .327 plus a slugging percentage of .351.

Cardinals Player Leaders

• Nolan Arenado has 11 doubles, a triple, 10 home runs and 23 walks while batting .247. He's slugging .404 with an on-base percentage of .310.
• Including all qualified players, he is 107th in batting average, while his on-base percentage is 114th and he is 105th in slugging.
• Arenado hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .300 with two home runs, two walks and three RBIs.
• Brendan Donovan's .377 OBP and .429 slugging percentage both lead his team. He has a batting average of .308.
• Including all qualified hitters, he is 10th in batting average, 21st in on-base percentage and 80th in slugging percentage.
• Lars Nootbaar is hitting .229 with 13 doubles, nine home runs and 43 walks.
• Willson Contreras is batting .241 with 16 doubles, 10 home runs and 25 walks.

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