Cardinals vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for April 27

Odds updated as of 5:14 a.m.

The St. Louis Cardinals are among the MLB squads busy on Sunday, up against the Milwaukee Brewers.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Brewers Game Info

• St. Louis Cardinals (12-15) vs. Milwaukee Brewers (13-15)
• Date: Sunday, April 27, 2025
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMWX and FDSWI

Cardinals vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-110) | MIL: (-106)
• Spread: STL: +1.5 (-184) | MIL: -1.5 (+152)
• Total: 8 -- Over: (-106) | Under: (-114)

Cardinals vs Brewers Probable Starting Pitchers

Probable Pitchers: Erick Fedde (Cardinals) - 1-2, 3.33 ERA vs José Quintana (Brewers) - 3-0, 0.96 ERA

The Cardinals will give the ball to Erick Fedde (1-2, 3.33 ERA), who is eyeing win No. 2 on the season, and the Brewers will turn to Jose Quintana (3-0, 0.96 ERA). Fedde and his team are 2-3-0 ATS this season when he starts. Fedde's team lost his only start as a favorite this season. In each of Quintana's three starts that had a set spread, the Brewers covered. The Brewers were the underdog on the moneyline for two Quintana starts this season -- they won both.

Cardinals vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (52.3%)

Cardinals vs Brewers Moneyline

• The moneyline numbers for Cardinals vs. Brewers reveal St. Louis as the favorite (-110) and Milwaukee as the underdog (-106) on the road.

Cardinals vs Brewers Spread

• The Brewers are 1.5-run favorites against the spread for this matchup with the Cardinals. The Brewers are +152 to cover, while the Cardinals are -184 to cover as a 1.5-run underdog on the runline.

Cardinals vs Brewers Over/Under

• The over/under for the Cardinals versus Brewers contest on April 27 has been set at 8, with -106 odds on the over and -114 odds on the under.

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Cardinals vs Brewers Betting Trends

• The Cardinals have been victorious in four of the eight contests they have been chosen as favorites in this season.
• This year St. Louis has won four of eight games when listed as at least -110 on the moneyline.
• The Cardinals and their opponents have gone over in 15 of their 27 games with a total set by sportsbooks this season.
• The Cardinals are 12-15-0 against the spread in their 27 games with a line set by sportsbooks this season.
• The Brewers have won 21.4% of the games this season they were the moneyline underdog (3-11).
• When it has played as a moneyline underdog with odds of -106 or longer, Milwaukee has a 3-11 record (winning just 21.4% of its games).
• The Brewers have had an over/under set by oddsmakers 28 times, and have combined with opponents to go over the total in 12 of those games (12-16-0).
• The Brewers have collected a 16-12-0 record ATS this season (covering 57.1% of the time).

Cardinals Player Leaders

• Lars Nootbaar is batting .263 with four doubles, four home runs and 22 walks. He has an on-base percentage of .402 while slugging .424.
• He ranks 63rd in batting average, 14th in on-base percentage, and 67th in slugging among qualifying batters in MLB.
• Nootbaar hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .300 with a double, a home run, five walks and six RBI.
• Brendan Donovan has 36 hits and an OBP of .406 to go with a slugging percentage of .541. All three of those stats are tops among St. Louis hitters this season. He's batting .367.
• Among qualifying hitters, his batting average ranks him second, his on-base percentage 12th, and his slugging percentage 21st.
• Donovan enters this game looking to extend his four-game hit streak. During his last five outings he is batting .316 with two doubles, two walks and two RBI.
• Nolan James Arenado has 25 hits this season and has a slash line of .266/.367/.447.
• Arenado heads into this game with three games in a row with at least one hit. In his last five games he is batting .190 with two doubles, a home run, two walks and two RBI.
• Victor Scott II has one home run, 10 RBI and a batting average of .264 this season.

Brewers Player Leaders

• Jackson Chourio has put up 33 hits, a team-best for the Brewers. He's batting .280 and slugging .534 with an on-base percentage of .295.
• Including all qualified hitters in the big leagues, he ranks 40th in batting average, 108th in on-base percentage and 23rd in slugging percentage.
• Brice Turang leads his team with a .420 slugging percentage. He has a batting average of .321 with an on-base percentage of .366.
• He is currently 13th in batting average, 36th in on-base percentage and 71st in slugging percentage among all qualified hitters.
• Christian Yelich is hitting .227 with three doubles, five home runs and 15 walks.
• Sal Frelick has four doubles, two triples, a home run and 11 walks while batting .303.

Cardinals vs Brewers Head to Head

• 4/26/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/25/2025: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2024: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2024: 7-4 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2024: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/22/2024: 3-0 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/21/2024: 10-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/20/2024: 3-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/12/2024: 4-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/11/2024: 5-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)

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