Broncos vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 2

The Denver Broncos will take on the Indianapolis Colts in NFL action on Sunday.
We've got you covered, in terms of the most important information about NFL betting lines, before you make your wager on FanDuel Sportsbook.
Broncos vs Colts Prediction & Pick
All NFL win probability predictions and picks are according to numberFire.
Prediction: Broncos win (55.3%)
Broncos vs Colts Point Spread
The Broncos are 2.5-point favorites against the Colts. The Broncos are -102 to cover the spread, while the Colts are -120 to cover as a 2.5-point underdog.
Broncos vs Colts Over/Under
An over/under of 42.5 has been set for Broncos-Colts on Sept. 14, with the over being -110 and the under -110.
Broncos vs Colts Moneyline
Looking at the moneyline for Colts-Broncos, Indianapolis is the underdog at +106, and Denver is -124 playing on the road.
Broncos vs Colts Betting Trends
- Against the spread, the Broncos were 12-5-0 last season.
- The Broncos covered every time (7-0) as a 2.5-point favorite or more last year.
- Denver had 11 of its 17 games hit the over last year.
- The Colts beat the spread nine times in 17 games last year.
- Against the spread, as underdogs of 2.5 points or more, Indianapolis went 5-4 last year.
- Last year, 10 of the Colts' 17 games went over the point total.
Check out even more in-depth Broncos vs. Colts analysis on FanDuel Research.
Broncos vs Colts Odds & Spread
- All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
- Moneyline: DEN: (-124) | IND: (+106)
- Spread: DEN: -2.5 (-102) | IND: +2.5 (-120)
- Total: 42.5 -- Over: (-110) | Under: (-110)
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