Bills vs Patriots Prediction, Odds, Picks, Best Bets for NFL Week 4

The Sunday schedule in the NFL includes a matchup between the Buffalo Bills and the New England Patriots.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Bills vs Patriots Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (74.4%)

Bills vs Patriots Point Spread

The Bills are 6.5-point favorites against the Patriots. The Bills are -118 to cover the spread, while the Patriots are -104 to cover as a 6.5-point underdog.

Bills vs Patriots Over/Under

The Bills-Patriots matchup on Oct. 4 has been given an over/under of 48.5 points. The over is -110 and the under is -110.

Bills vs Patriots Moneyline

The moneyline numbers for Bills vs. Patriots reveal Buffalo as the favorite (-330) and New England as the underdog (+265) on the road.

Bills vs Patriots Betting Trends

• Buffalo is 3-0-0 against the spread this year.
• The Bills are unbeaten ATS (1-0) as a 6.5-point favorite or greater this year.
• Two of the Bills' three games have hit the over.
• The Patriots have two wins against the spread this year.
• No Patriots game has gone over the point total this season.

Check out even more in-depth Bills vs. Patriots analysis on FanDuel Research.

Bills vs Patriots Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-330) | NE: (+265)
• Spread: BUF: -6.5 (-118) | NE: +6.5 (-104)
• Total: 48.5 -- Over: (-110) | Under: (-110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!