Bills vs 49ers Prediction, Odds, Picks, Best Bets for NFL Week 13 Sunday Night Football

The NFL schedule on Sunday includes the Buffalo Bills taking on the San Francisco 49ers.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NFL betting odds.

Bills vs 49ers Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (72.9%)

Bills vs 49ers Point Spread

The Bills are 6.5-point favorites against the 49ers. The Bills are -105 to cover the spread, while the 49ers are -115 to cover as a 6.5-point underdog.

Bills vs 49ers Over/Under

A combined point total of 44.5 has been set for Bills-49ers on Dec. 1, with the over at -110 and the under at -110.

Bills vs 49ers Moneyline

The Bills vs 49ers moneyline has Buffalo as a -280 favorite, while San Francisco is a +230 underdog on the road.

Bills vs 49ers Betting Trends

• Buffalo's record against the spread is 7-4-0.
• The Bills have won once ATS (1-1) as a 6.5-point favorite or more this season.
• There have been seven Bills games (out of 11) that went over the total this season.
• The 49ers have four wins in 11 contests against the spread this year.
• San Francisco has no wins ATS (0-1) as a 6.5-point underdog or more this season.
• There have been six 49ers games (out of 11) that hit the over this year.

Bills vs 49ers Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-280) | SF: (+230)
• Spread: BUF: -6.5 (-105) | SF: +6.5 (-115)
• Total: 44.5 -- Over: (-110) | Under: (-110)

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