Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 3

Odds updated as of 7:11 a.m.

MLB action on Saturday includes the Houston Astros playing the Chicago White Sox.

We've got you covered, in terms of the vital information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Astros vs White Sox Game Info

• Houston Astros (16-15) vs. Chicago White Sox (9-23)
• Date: Saturday, May 3, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SCHN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-250) | CHW: (+205)
• Spread: HOU: -1.5 (-146) | CHW: +1.5 (+122)
• Total: 8 -- Over: (-112) | Under: (-108)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 4-1, 1.22 ERA vs Davis Martin (White Sox) - 1-3, 3.24 ERA

This contest's pitching matchup is set, as the Astros will send Hunter Brown (4-1) to the mound, while Davis Martin (1-3) will take the ball for the White Sox. When Brown starts, his team is 4-2-0 against the spread this season. Brown's team has a record of 3-2 this season when he starts and they are the favorite on the moneyline. The White Sox have a 2-3-0 record against the spread in Martin's starts. The White Sox have been the underdog on the moneyline in five of Martin's starts this season, and they went 1-4 in those games.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (66.4%)

Astros vs White Sox Moneyline

• Chicago is the underdog, +205 on the moneyline, while Houston is a -250 favorite despite being on the road.

Astros vs White Sox Spread

• The White Sox are hosting the Astros, and are +1.5 on the runline. The White Sox are -146 to cover the spread, and the Astros are +122.

Astros vs White Sox Over/Under

• A combined run total of 8 has been set for Astros-White Sox on May 3, with the over at -112 and the under at -108.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have come away with 11 wins in the 22 contests they have been listed as the favorites in this season.
• Houston has not played a game this season with better moneyline odds than -250.
• The Astros' games have gone over the total in 13 of their 31 opportunities.
• The Astros have an against the spread record of 17-14-0 in 31 games with a line this season.
• The White Sox have won 28.1% of the games this season they were the underdog on the moneyline (9-23).
• Chicago has gone 1-3 when it has played as a moneyline underdog with odds of +205 or longer (25%).
• The White Sox have played in 32 games with a set over/under, and have combined with their opponents to go over the total 15 times (15-15-2).
• The White Sox have covered 53.1% of their games this season, going 17-15-0 ATS.

Astros Player Leaders

• Jeremy Pena leads Houston with 32 hits, batting .278 this season with nine extra-base hits. He has an on-base percentage of .349 and a slugging percentage of .426.
• He ranks 41st in batting average, 52nd in on-base percentage, and 66th in slugging among qualifying hitters in MLB.
• Pena hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is hitting .385 with two doubles, a home run, three walks and five RBI.
• Isaac Paredes leads Houston in OBP (.358) this season, fueled by 29 hits. He's batting .252 while slugging .400.
• Among qualified hitters, his batting average places him 77th, his on-base percentage 46th, and his slugging percentage 91st.
• Paredes has picked up a hit in four straight games. In his last five games he is batting .235 with a triple, five walks and an RBI.
• Jose Altuve leads Houston in slugging percentage (.393) powered by seven extra-base hits.
• Altuve takes a two-game hitting streak into this game. In his last five games he is batting .211 with a double, a home run, four walks and five RBI.
• Yordan Alvarez has three home runs, 18 RBI and a batting average of .210 this season.

White Sox Player Leaders

• Luis Robert has 20 hits with a .310 on-base percentage, leading the White Sox in both statistics. He's batting .189 and slugging .358.
• Including all qualifying hitters, he is 150th in batting average, while his on-base percentage ranks 96th and he is 117th in slugging.
• Robert hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is hitting .270 with two doubles, three home runs, seven walks and eight RBI.
• Miguel Vargas leads his team with a .310 OBP. He has a batting average of .216 while slugging .324.
• Including all qualified hitters, he is 121st in batting average, 96th in on-base percentage and 139th in slugging percentage.
• Andrew Benintendi is batting .231 with five home runs and eight walks.
• Brooks Baldwin is batting .242 with five doubles, three home runs and four walks.

Astros vs White Sox Head to Head

• 5/2/2025: 7-3 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/18/2024: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/17/2024: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 8/16/2024: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/20/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 6/19/2024: 4-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/18/2024: 2-0 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/14/2023: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/13/2023: 3-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/12/2023: 5-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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