Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for AL Wild Card Game 1 on Sept. 29

Odds updated as of 5:11 p.m.

The Houston Astros will take on the Chicago White Sox in Game 1 of the AL Wild Card Series on Tuesday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs White Sox Game Info

• Houston Astros (81-81) vs. Chicago White Sox (84-78)
• Date: Tuesday, September 29, 2026
• Time: 5 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: NBCSN and Peacock

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-120) | CHW: (+102)
• Spread: HOU: +1.5 (-196) | CHW: -1.5 (+162)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: A.J. Blubaugh (Astros) - 5-3, 3.66 ERA vs Hagen Smith (White Sox) - 3-3, 1.29 ERA

The probable pitchers are A.J. Blubaugh (5-3, 3.66 ERA) for the Astros and Hagen Smith (3-3, 1.29 ERA) for the White Sox. In games Blubaugh pitched with a spread last season, his team was 2-1-0 ATS. Blubaugh and his team won as favorites in 50% of his two appearances last season with a moneyline. Smith has started only one game with a set spread, which the White Sox failed to cover. The White Sox have not been the underdog on the moneyline when Smith starts this season.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (59.2%)

Astros vs White Sox Moneyline

• Looking at the moneyline for Astros-White Sox, Houston is the favorite at -120, and Chicago is +102 playing on the road.

Astros vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Astros. The White Sox are +162 to cover, while the Astros are -196 to cover as a 1.5-run underdog on the runline.

Astros vs White Sox Over/Under

• A combined run total of 8.5 has been set for Astros-White Sox on Sept. 29, with the over at -106 and the under at -114.

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Astros vs White Sox Betting Trends

• The Astros have been favorites in 72 games this season and have come away with the win 38 times (52.8%) in those contests.
• This season Houston has been victorious 30 times in 60 chances when named as a favorite of at least -120 on the moneyline.
• Contests with the Astros have gone over the total set by bookmakers in 80 of 162 chances this season.
• In 162 games with a line this season, the Astros have a mark of 82-80-0 against the spread.
• The White Sox have put together a 50-55 record in games they were listed as the moneyline underdog (winning 47.6% of those games).
• In games it has played as a moneyline underdog with odds of +102 or longer, Chicago has a 40-44 record (winning 47.6% of its games).
• The White Sox have combined with opponents to hit the over on the total 89 times this season for an 89-69-1 record against the over/under.
• The White Sox have collected a 90-69-0 record against the spread this season (covering 56.6% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston in OBP (.432), slugging percentage (.601) and total hits (179) this season. He has a .316 batting average.
• Among qualified hitters in MLB, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Alvarez will look for his 13th straight game with a hit in this matchup. In his last 10 outings he is batting .395 with three doubles, three home runs, six walks and eight RBIs.
• Isaac Paredes is hitting .262 with 27 doubles, a triple, 25 home runs and 71 walks, while slugging .447 with an on-base percentage of .360.
• Among qualifying hitters, his batting average ranks him 56th, his on-base percentage 30th, and his slugging percentage 49th.
• Christian Walker has 129 hits this season and has a slash line of .226/.299/.427.
• Walker enters this matchup with six games in a row with at least one hit. In his last 10 outings he is batting .263 with a double, four home runs, four walks and seven RBIs.
• Jeremy Pena has been key for Houston with 124 hits, an OBP of .325 plus a slugging percentage of .477.
• Pena brings a two-game hitting streak into this game. In his last five games he is hitting .320 with two home runs and five RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He's slugging .474 with an on-base percentage of .363.
• Including all qualified hitters in the majors, he is 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth's .415 slugging percentage paces his team. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualifying hitters, his batting average places him 33rd, his on-base percentage is 45th, and he is 80th in slugging.
• Sam Antonacci has racked up an on-base percentage of .370, a team-high for the White Sox.
• Munetaka Murakami has racked up 94 hits to pace his team.

Astros vs White Sox Head to Head

• 9/3/2026: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/2/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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