Astros vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 13

Odds updated as of 8:13 a.m.

The MLB slate on Wednesday includes the Houston Astros taking on the Boston Red Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Red Sox Game Info

• Houston Astros (67-53) vs. Boston Red Sox (66-55)
• Date: Wednesday, August 13, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NESN

Astros vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-178) | BOS: (+150)
• Spread: HOU: -1.5 (+120) | BOS: +1.5 (-144)
• Total: 8 -- Over: (-105) | Under: (-115)

Astros vs Red Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 9-5, 2.51 ERA vs Walker Buehler (Red Sox) - 7-6, 5.40 ERA

The Astros will give the nod to Hunter Brown (9-5) against the Red Sox and Walker Buehler (7-6). When Brown starts, his team is 13-10-0 against the spread this season. Brown's team has won 61.1% of his starts when they are favored on the moneyline (11-7). When Buehler starts, the Red Sox have gone 12-8-0 against the spread. The Red Sox have a 4-5 record in Buehler's nine starts this season when they were the underdog on the moneyline.

Astros vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (64.1%)

Astros vs Red Sox Moneyline

• Houston is a -178 favorite on the moneyline, while Boston is a +150 underdog on the road.

Astros vs Red Sox Spread

• The Red Sox are +1.5 on the spread (-144 to cover), and Houston is +120 to cover the runline.

Astros vs Red Sox Over/Under

• An over/under of 8 has been set for Astros-Red Sox on Aug. 13, with the over being -105 and the under -115.

Bet on Houston Astros vs. Boston Red Sox on FanDuel today!

Astros vs Red Sox Betting Trends

• The Astros have been favorites in 77 games this season and have come away with the win 41 times (53.2%) in those contests.
• Houston has not played a game this season with better moneyline odds than -178.
• Contests with the Astros have gone over the total set by oddsmakers in 53 of 119 chances this season.
• The Astros are 60-59-0 against the spread in their 119 games that had a posted line this season.
• The Red Sox have been the underdog on the moneyline 43 total times this season. They've finished 20-23 in those games.
• Boston has never played a game this season with moneyline odds of +150 or longer.
• The Red Sox have played in 120 games with a set over/under, and have combined with opponents to go over the total 59 times (59-56-5).
• The Red Sox are 68-52-0 against the spread this season.

Astros Player Leaders

• Jose Altuve leads Houston in slugging percentage (.472) thanks to 40 extra-base hits. He has a .285 batting average and an on-base percentage of .349.
• He is 22nd in batting average, 44th in on-base percentage, and 37th in slugging among all qualified hitters in baseball.
• Jeremy Pena has 114 hits and an OBP of .374, both of which lead the Astros this season. He's batting .318 and slugging .486.
• Among qualified batters, his batting average ranks him second, his on-base percentage 13th, and his slugging percentage 30th.
• Pena has picked up at least one hit in two straight games. In his last five games he is batting .227 with a home run, a walk and an RBI.
• Yainer Diaz is batting .251 with a .414 slugging percentage and 50 RBI this year.
• Christian Walker is batting .235 with a .300 OBP and 65 RBI for Houston this season.

Red Sox Player Leaders

• Jarren Duran has a .335 on-base percentage and a .456 slugging percentage, both team-best marks for the Red Sox. He's batting .265.
• Including all the qualified hitters in MLB, he is 61st in batting average, 65th in on-base percentage and 58th in slugging percentage.
• Ceddanne Rafaela is hitting .259 with 24 doubles, three triples, 14 home runs and 20 walks. He's slugging .438 with an on-base percentage of .301.
• He is 77th in batting average, 130th in on-base percentage and 73rd in slugging percentage in the majors.
• Trevor Story is batting .256 with 19 doubles, 18 home runs and 25 walks.
• Wilyer Abreu leads his team with 85 hits.

Astros vs Red Sox Head to Head

• 8/12/2025: 14-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/11/2025: 7-6 HOU (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/3/2025: 6-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/2/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 8/1/2025: 2-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/21/2024: 4-1 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/20/2024: 6-5 BOS (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/19/2024: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/11/2024: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/10/2024: 5-4 HOU (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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