Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 9:12 a.m.

The Houston Astros are among the MLB teams in action on Friday, up against the Seattle Mariners.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Mariners Game Info

• Houston Astros (26-24) vs. Seattle Mariners (28-21)
• Date: Friday, May 23, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-126) | SEA: (+108)
• Spread: HOU: -1.5 (+162) | SEA: +1.5 (-196)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Ryan Gusto (Astros) - 3-2, 4.65 ERA vs Emerson Hancock (Mariners) - 1-2, 6.21 ERA

The Astros will call on Ryan Gusto (3-2) versus the Mariners and Emerson Hancock (1-2). Gusto and his team are 3-2-0 ATS this season when he starts. Gusto's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 3-2. The Mariners are 5-2-0 ATS in Hancock's seven starts that had a set spread. The Mariners have been the moneyline underdog in five of Hancock's starts this season, and they went 4-1 in those games.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53%)

Astros vs Mariners Moneyline

• Houston is the favorite, -126 on the moneyline, while Seattle is a +108 underdog on the road.

Astros vs Mariners Spread

• The Astros are hosting the Mariners and are favored by 1.5 runs on the spread. The Astros are +162 to cover the runline, with the Mariners being -196.

Astros vs Mariners Over/Under

• A combined run total of 8.5 has been set for Astros-Mariners on May 23, with the over at -115 and the under at -105.

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Astros vs Mariners Betting Trends

• The Astros have been victorious in 18, or 54.5%, of the 33 contests they have been chosen as favorites in this season.
• This season Houston has come away with a win 12 times in 22 chances when named as a favorite of at least -126 on the moneyline.
• The Astros and their opponents have gone over in 21 of their 50 games with a total set by sportsbooks this season.
• In 50 games with a line this season, the Astros have a mark of 27-23-0 against the spread.
• The Mariners have an 11-8 record in games they were listed as the moneyline underdog (winning 57.9% of those games).
• In games it has played as a moneyline underdog with odds of +108 or longer, Seattle has gone 8-3 (72.7%).
• The Mariners have combined with opponents to hit the over on the total 27 times this season for a 27-19-2 record against the over/under.
• The Mariners have gone 24-24-0 ATS this season.

Astros Player Leaders

• Isaac Paredes leads Houston with 48 hits and an OBP of .374 this season. He has a .264 batting average and a slugging percentage of .473.
• Among all qualified batters in the majors, he is 65th in batting average, 25th in on-base percentage, and 45th in slugging.
• Jeremy Pena leads Houston in slugging percentage (.447) thanks to 15 extra-base hits. He's batting .298 with an on-base percentage of .362.
• Among qualifying batters, he is 21st in batting average, 40th in on-base percentage and 59th in slugging percentage.
• Jake Meyers has collected 45 base hits, an OBP of .366 and a slugging percentage of .426 this season.
• Meyers has recorded at least one base hit in seven straight games. In his last 10 games he is hitting .324 with a double, a home run, three walks and two RBIs.
• Jose Altuve is batting .243 with a .296 OBP and 18 RBI for Houston this season.

Mariners Player Leaders

• Cal Raleigh has accumulated a slugging percentage of .579 and has 45 hits, both team-best figures for the Mariners. He's batting .253 and with an on-base percentage of .371.
• Including all qualified players in the majors, he is 85th in batting average, 32nd in on-base percentage and fifth in slugging percentage.
• Raleigh enters this matchup on a three-game hitting streak. During his last five outings he is hitting .250 with two doubles, a home run, two walks and two RBIs.
• Julio Rodriguez's .415 slugging percentage leads his team. He has a batting average of .231 with an on-base percentage of .309.
• He is 118th in batting average, 108th in on-base percentage and 82nd in slugging percentage in MLB.
• Jorge Polanco has six doubles, 10 home runs and nine walks while batting .291.
• J.P. Crawford has a .386 OBP to lead his team.

Astros vs Mariners Head to Head

• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/19/2024: 3-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)

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