Astros vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 7

Odds updated as of 9:11 a.m.

The Houston Astros will face the Cleveland Guardians in MLB action on Saturday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Astros vs Guardians Game Info

• Houston Astros (35-28) vs. Cleveland Guardians (33-29)
• Date: Saturday, June 7, 2025
• Time: 4:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and SCHN

Astros vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-120) | CLE: (+102)
• Spread: HOU: -1.5 (+146) | CLE: +1.5 (-178)
• Total: 7 -- Over: (-122) | Under: (-100)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 8-3, 1.83 ERA vs Gavin Williams (Guardians) - 5-3, 3.79 ERA

This contest's pitching matchup is set, as the Astros will send Hunter Brown (8-3) to the mound, while Gavin Williams (5-3) will get the nod for the Guardians. Brown and his team are 8-4-0 ATS this season when he starts. Brown's team has won 70% of his starts when they are favored on the moneyline (7-3). The Guardians have a 7-5-0 record against the spread in Williams' starts. The Guardians are 4-3 in Williams' seven starts this season that they were the moneyline underdog.

Astros vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (58.8%)

Astros vs Guardians Moneyline

• Looking at the moneyline for Astros-Guardians, Houston is the favorite at -120, and Cleveland is +102 playing at home.

Astros vs Guardians Spread

• The Astros are favored by 1.5 runs on the road versus the Guardians. The Astros are +146 to cover the spread, while the Guardians are -178.

Astros vs Guardians Over/Under

• The Astros-Guardians game on June 7 has been given an over/under of 7 runs. The over is set at -122 and the under at -100.

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Astros vs Guardians Betting Trends

• The Astros have won in 23, or 54.8%, of the 42 contests they have been named as odds-on favorites in this year.
• This year Houston has won 18 of 31 games when listed as at least -120 on the moneyline.
• Contests with the Astros have gone over the total set by oddsmakers in 24 of 62 chances this season.
• In 62 games with a line this season, the Astros have a mark of 33-29-0 against the spread.
• The Guardians have won 47.4% of the games this season they were the underdog on the moneyline (18-20).
• Cleveland has an 11-17 record (winning only 39.3% of its games) when playing as a moneyline underdog of +102 or longer.
• In the 60 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 27 times (27-31-2).
• The Guardians have collected a 29-31-0 record against the spread this season (covering 48.3% of the time).

Astros Player Leaders

• Jeremy Pena leads Houston with 78 hits and an OBP of .382, plus a team-best slugging percentage of .494. He's batting .324.
• Among all qualified batters, he is sixth in batting average, his on-base percentage ranks 15th, and he is 29th in slugging.
• Pena has recorded a base hit in 12 games in a row. During his last 10 games he is hitting .463 with four doubles, three home runs, two walks and six RBIs.
• Isaac Paredes has seven doubles, a triple, 14 home runs and 34 walks. He's batting .254 and slugging .474 with an on-base percentage of .356.
• Among qualified hitters, his batting average ranks him 89th, his on-base percentage 39th, and his slugging percentage 45th.
• Paredes has picked up at least one hit in two games in a row. In his last five games he is hitting .222 with three home runs, four walks and five RBIs.
• Jose Altuve is batting .267 with a .404 slugging percentage and 24 RBI this year.
• Altuve heads into this game with four games in a row with at least one hit. During his last five outings he is batting .250 with a walk and two RBIs.
• Jake Meyers has three home runs, 16 RBI and a batting average of .286 this season.

Guardians Player Leaders

• Jose Ramirez has racked up 75 hits with a .382 on-base percentage and a .544 slugging percentage, all club-bests for the Guardians. He's batting .329.
• Including all qualifying hitters in MLB, he is fourth in batting average, 15th in on-base percentage and 11th in slugging percentage.
• Ramirez brings a six-game hitting streak into this game. In his last 10 outings he is hitting .425 with four doubles, two home runs, three walks and three RBIs.
• Steven Kwan is batting .306 with 13 doubles, five home runs and 20 walks. He's slugging .426 with an on-base percentage of .367.
• He ranks 13th in batting average, 32nd in on-base percentage and 80th in slugging percentage in MLB.
• Carlos Santana is hitting .256 with six doubles, seven home runs and 31 walks.
• Kyle Manzardo has six doubles, two triples, 11 home runs and 23 walks while hitting .210.

Astros vs Guardians Head to Head

• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/28/2024: 4-3 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/27/2024: 5-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2024: 8-2 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/1/2024: 3-2 CLE (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/30/2024: 10-9 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/2/2023: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/1/2023: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/31/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/11/2023: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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