Astros vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for June 29

Odds updated as of 2:12 a.m.

The Houston Astros versus the Chicago Cubs is on the MLB schedule for Sunday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Astros vs Cubs Game Info

• Houston Astros (49-34) vs. Chicago Cubs (49-34)
• Date: Sunday, June 29, 2025
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN

Astros vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | CHC: (+136)
• Spread: HOU: -1.5 (+130) | CHC: +1.5 (-156)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Astros vs Cubs Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 8-4, 2.88 ERA vs Jameson Taillon (Cubs) - 7-5, 4.47 ERA

The Astros will give the nod to Framber Valdez (8-4) versus the Cubs and Jameson Taillon (7-5). When Valdez starts, his team is 6-9-0 against the spread this season. When Valdez starts a game and his team is the favorite on the moneyline, they have a record of 8-5. The Cubs are 7-8-0 ATS in Taillon's 15 starts with a set spread. The Cubs are 1-3 in Taillon's four starts this season that they were the moneyline underdog.

Astros vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (58.7%)

Astros vs Cubs Moneyline

• Chicago is a +136 underdog on the moneyline, while Houston is a -162 favorite at home.

Astros vs Cubs Spread

• The Cubs are at +1.5 on the runline against the Astros. The Cubs are -156 to cover the spread, and the Astros are +130.

Astros vs Cubs Over/Under

• Astros versus Cubs on June 29 has an over/under of 7.5 runs, with the odds on the over -120 and the under set at -102.

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Astros vs Cubs Betting Trends

• The Astros have been victorious in 34, or 59.6%, of the 57 contests they have been chosen as favorites in this season.
• This season Houston has come away with a win 10 times in 16 chances when named as a favorite of at least -162 on the moneyline.
• The Astros and their opponents have hit the over in 33 of their 82 games with a total set by oddsmakers this season.
• The Astros are 42-40-0 against the spread in their 82 games with a line set by sportsbooks this season.
• The Cubs have won 38.5% of the games this season they were the moneyline underdog (10-16).
• Chicago has a record of 2-2 when it has played as a moneyline underdog with odds of +136 or longer (50%).
• In the 81 games bookmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 44 times (44-33-4).
• The Cubs have covered 50.6% of their games this season, going 41-40-0 ATS.

Astros Player Leaders

• Jeremy Pena leads Houston with 102 hits and an OBP of .378, plus a team-best slugging percentage of .489. He's batting .322.
• Among qualified batters in the majors, his batting average ranks fourth, his on-base percentage ranks 19th, and he is 29th in slugging.
• Isaac Paredes is batting .254 with 10 doubles, a triple, 17 home runs and 42 walks. He's slugging .471 with an on-base percentage of .360.
• Among qualifying batters, he ranks 89th in batting average, 34th in on-base percentage and 47th in slugging percentage.
• Paredes brings a two-game streak with at least one hit into this one. In his last five games he is hitting .222 with a home run, a walk and an RBI.
• Jose Altuve has collected 80 base hits, an OBP of .320 and a slugging percentage of .410 this season.
• Jake Meyers has three home runs, 20 RBI and a batting average of .307 this season.
• Meyers enters this game on a four-game hitting streak. During his last five outings he is hitting .250 with a walk.

Cubs Player Leaders

• Kyle Tucker has an on-base percentage of .396 and a slugging percentage of .537. Both lead the Cubs. He's batting .291.
• Including all qualifying hitters, he is 23rd in batting average, while his on-base percentage ranks fourth and he is 11th in slugging.
• Pete Crow-Armstrong has 20 doubles, three triples, 21 home runs and 15 walks while batting .266. He's slugging .544 with an on-base percentage of .302.
• His batting average is 62nd among all qualified players, his on-base percentage is 124th, and he is 10th in slugging.
• Seiya Suzuki is leading the Cubs with 83 hits.
• Nico Hoerner is batting .294 with 17 doubles, a triple, three home runs and 17 walks.

Astros vs Cubs Head to Head

• 6/28/2025: 12-3 CHC (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/27/2025: 7-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/25/2024: 3-1 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/24/2024: 4-3 CHC (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/23/2024: 7-2 CHC (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/17/2023: 7-6 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/16/2023: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/15/2023: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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